Jerry Crabtree

The Crabtree Lab

We are interested in the role of epigenetic mechanisms in the development of the nervous system and also in cancer. We focus primarily on the role of an ATP-dependent chromatin remodeling complex called mSWI/SNF or BAF that is frequently mutated in cancer and neurodevelopmental diseases. We are also developing new techniques based on chemically induced proximity to explore and understand how these mechanisms relate to autism, speech disorders and intellectual disability.

Research

Understanding the Words of Chromatin Remodeling

We are exploring the role of chromatin regulation in verebrate development using genetic, proteomic and genomic approaches in mice.

Design of Small Molecule Regulators

A general problem in signal transduction and transcription is the mechanism by which signals of different intensities are converted to different cell fates.

Popular Press

Presidental Award for 2014 to Andrew Yoo

Presidental Award for 2014 to Andrew Yoo

Cigal Kadoch Receives Forbes’ 30-under-30 Award

Cigal Kadoch Receives Forbes' 30-under-30 Award
Forbes

New Way to Build Stronger Bones

New Way to Build Stronger Bones
BBC News

Lilly Reports Sepsis Drug Passes Advanced Trials

Lilly Reports Sepsis Drug Passes Advanced Trials
NY Times