The Crabtree Lab
Home Page and Lab Interest Lab Members and how to contact them.. The things we send out: clones, cell lines, protocols and mice- Articles in the popular press about the Crabtree lab Past Lab Members

Current Laboratory Members: The Lab Kids and How to Find Them

The lab phone numbers are

B209 650 723 7671, fax is 723 5158

B207 650 725 5820

B203 650 725 8091

Jerry Crabtree: crabtree at

Administrative Assistant:

Penny Brueggmann: pbruegge at

Mamoun Alhamadsheh: mamoun at

Oliver Bell: olibell at

Lei Chen: leichen at

Emily Dykhuize: dykhuize at

Laura Elias: lelias at stanford,edu

Nate Hathway: Natehat3 at

Lena Ho: lenaho at

Wen Qi Ho: hwenqi at

Ann Kuo: annkuo at

Fu-Sen Liang:fsliang at

Dana Neel: dsn2011 at

Dorothy Park: Dorothyp at

Alberto Polleri: polleri at

Amy Radermacher: amyrader at

Jehnna Ronan: jronan at

Ary (Aryaman) Shalizi: shalizi at

Brett Staahl: bstaahl at

Alfred Sun: Alfreds at

Jiong Tang: Jtang1 at

Andrew Yoo: asyoo at



 Some Recent Articles

Lena Ho, Raja Jothi, Jehnna L. Ronan, Kairong Cui, Keji Zhao, Gerald R. Crabtree, An Embryonic Stem Cell Chromatin Remodeling Complex, esBAF is an Essential Component of the Core Pluripotency Transcriptional Network PNAS in press 2009

Lena Ho, Jehnna L. Ronan, Jiang Wu, Brett Staahl, Lei Chen, Ann Kuo, Julie Lessard, Alexey I. Nesvizhskii,
Jeff Ranish, and Gerald R. Crabtree, An embryonic stem cell chromatin remodelingcomplex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency PNAS in press 2009

Jiang Wu, Julie Lessard and Gerald R. Crabtree; Understanding the Words of Chromatin Regulation Cell Jan 23 2009

Shih-Chu Kao, Hai Wu, Jianming Xie, Ching-Pin Chang, Jeffrey A. Ranish, Isabella A. Graef, and Gerald R. Crabtree; Calcineurin/NFAT Signaling Is Required for Neuregulin-Regulated Schwann Cell Differentiation Science Jan 30 2009

Elena M Gallo, Ho L, Winslow MM, Staton TL, Crabtree GR.Selective role of calcineurin in haematopoiesis and lymphopoiesis.
EMBO Rep. 2008 PMID: 18818667

Gallo EM, Winslow MM, Canté-Barrett K, Radermacher AN, Ho L, McGinnis L, Iritani B, Neilson JR, Crabtree GR. Calcineurin sets the bandwidth for discrimination of signals during thymocyte development. Nature 450, 731-5 (2007).

Lessard J, Wu JI, Ranish JA, Wan M, Winslow MM, Staahl BT, Wu H, Aebersold R, Graef IA, Crabtree GR. An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron 55, 201-15 (2007).

Wu JI, Lessard J, Olave IA, Qiu Z, Ghosh A, Graef IA, Crabtree GR. Regulation of dendritic development by neuron-specific chromatin remodeling complexes. Neuron 56, 94-108 (2007).

Liu, K. J., Arron, J. R., Stankunas, K., Crabtree, G. R. & Longaker, M. T. Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice. Nature 446, 79-82 (2007).

Heit JJ, Apelqvist AA, Gu X, Winslow MM, Neilson JR, Crabtree GR, Kim SK. Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function. Nature 443, 345-9 (2006).

Jiang I. Wu and Gerald R. Crabtree Nuclear Actin as Choreographer of Cell Morphology and Transcription Science 22 June 2007 316: 1710-1711 PMID: 17588921

Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim SK, Yamasaki N, Miyakawa T, Francke U, Graef IA, Crabtree GR.NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature 441, 595-600 (2006).

Bayle JH, Grimley JS, Stankunas K, Gestwicki JE, Wandless TJ, Crabtree GR.  Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity.   Chem Biol. 2006 Jan;13(1):99-107.  PMID: 16426976

Winslow MM, Pan M, Starbuck M, Gallo EM, Deng L, Karsenty G, Crabtree GR. Calcineurin/NFAT signaling in osteoblasts regulates bone mass.  Dev Cell. 2006 Jun;10(6):771-82.

Winslow MM, Gallo EM, Neilson JR, Crabtree GR. The calcineurin phosphatase complex modulates immunogenic B cell responses.
Immunity. 2006 Feb;24(2):141-52

Winslow MM, Crabtree GR.  Immunology. Decoding calcium signaling.  Science. 2005 Jan 7;307(5706):56-7.   PMID: 15637261

Gestwicki J, Crabtree GR and Graef IA Harnessing Chaperones to Generate Potent Small Molecule Inhibitors of Amyloid Aggregation. Science, Oct 29, 2004 p 865-869, PDF or HTML For information from the popular press see BBC News, or Scientific American (PDF), or CNN News (PDF), or Chemical Engineering News, or HHMI Report, or ABC News

Chang, CP, Neilson, J.R. Bayle, J.H., Gestwicki, J.E., Kuo, a. Stankunas, K. Graef, IA and Crabtree G.R. A Field of Calcineurin-NFAT signaling underlies heart valve morphogenesis, Cell Sept 3rd 2004. Note the cover design and the accompanying editorial. PDF or HTLM for the paper, PDF or HTML for the Editorial

Neilson JR, Winslow MM, Hur EM, Crabtree GR.
Calcineurin B1 is essential for positive but not negative selection during thymocyte development. Immunity. 2004 Mar;20(3):255-66.

Stankunas et al. Condtional Protein Alleles Using Knock-in Mice and a Chemical Inducer of Dimerization Mol Cell Dec 12, 1615-1624, 2003.HTML PDF

Graef I.A. et al Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons.Cell. 2003 May 30;113(5):657-70. HTML PDF

Chi et al.Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.Nature. 2002 Jul 11;418(6894):195-9. HTML PDF

Bayle et. al. Hyperphenylalaninemia and impaired glucose tolerance in mice lacking the bifunctional DCoH gene.J Biol Chem. 2002 Aug 9;277(32):28884-91HTML

Rando OJ, et al. Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex.Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2824-9. HTML

Graef IA, et al. Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.Cell. 2001 Jun 29;105(7):863-75 HTML PDF

Graef IA, et al. L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons.Nature. 1999 Oct 14;401(6754):703-8 HTML PDF



The Crabtree lab 2007, Elena's Farewell Party

The Crabtree Lab 2006- Julie's Farewell Party

August 2003 at Tian and Mimi's Farewell Party: Tian on his way to New Haven.

Joel Neilson's Going Away Party Dec 17, 2004-

Logger Weekend

Joel Neilson



The Crabtree lab: 2001 Roger's Fishing trip

Tian and Mimi's Farewell Party August 2003




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