Gallo EM, Winslow MM, Canté-Barrett K, Radermacher AN, Ho L, McGinnis L, Iritani B, Neilson JR, Crabtree GR. Calcineurin sets the bandwidth for discrimination of signals during thymocyte development. Nature 450, 731-5 (2007).

Lessard J, Wu JI, Ranish JA, Wan M, Winslow MM, Staahl BT, Wu H, Aebersold R, Graef IA, Crabtree GR. An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron 55, 201-15 (2007).

Wu JI, Lessard J, Olave IA, Qiu Z, Ghosh A, Graef IA, Crabtree GR. Regulation of dendritic development by neuron-specific chromatin remodeling complexes. Neuron 56, 94-108 (2007).

Liu, K. J., Arron, J. R., Stankunas, K., Crabtree, G. R. & Longaker, M. T. Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice. Nature 446, 79-82 (2007).

Heit JJ, Apelqvist AA, Gu X, Winslow MM, Neilson JR, Crabtree GR, Kim SK. Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function. Nature 443, 345-9 (2006).

Jiang I. Wu and Gerald R. Crabtree Nuclear Actin as Choreographer of Cell Morphology and Transcription Science 22 June 2007 316: 1710-1711 PMID: 17588921

Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim SK, Yamasaki N, Miyakawa T, Francke U, Graef IA, Crabtree GR.NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature 441, 595-600 (2006).

Bayle JH, Grimley JS, Stankunas K, Gestwicki JE, Wandless TJ, Crabtree GR.  Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity.   Chem Biol. 2006 Jan;13(1):99-107.  PMID: 16426976

Winslow MM, Pan M, Starbuck M, Gallo EM, Deng L, Karsenty G, Crabtree GR. Calcineurin/NFAT signaling in osteoblasts regulates bone mass.  Dev Cell. 2006 Jun;10(6):771-82.

Winslow MM, Gallo EM, Neilson JR, Crabtree GR. The calcineurin phosphatase complex modulates immunogenic B cell responses.
Immunity. 2006 Feb;24(2):141-52

Mammucari C, Tommasi di Vignano A, Sharov AA, Neilson J, Havrda MC, Roop DR, Botchkarev VA, Crabtree GR, Dotto GP.  Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control.  Dev Cell. 2005 May;8(5):665-76.  PMID: 15866158

Winslow MM, Crabtree GR.  Immunology. Decoding calcium signaling.  Science. 2005 Jan 7;307(5706):56-7.   PMID: 15637261

Gallo EM, Cante-Barrett K, Crabtree GR.  Lymphocyte calcium signaling from membrane to nucleus.  Nat Immunol. 2006 Jan;7(1):25-32.  PMID: 16357855

Gestwicki J, Crabtree GR and Graef IA Harnessing Chaperones to Generate Potent Small Molecule Inhibitors of Amyloid Aggregation. Science, Oct 29, 2004 p 865-869, PDF or HTML For information from the popular press see BBC News, or Scientific American (PDF), or CNN News (PDF), or Chemical Engineering News, or HHMI Report, or ABC News

Chang, CP, Neilson, J.R. Bayle, J.H., Gestwicki, J.E., Kuo, a. Stankunas, K. Graef, IA and Crabtree G.R. A Field of Calcineurin-NFAT signaling underlies heart valve morphogenesis, Cell Sept 3rd 2004. Note the cover design and the accompanying editorial. PDF or HTLM for the paper, PDF or HTML for the Editorial

Rose RB, Pullen KE, Bayle JH, Crabtree GR, Alber T.Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2.
Biochemistry. 2004 Jun 15;43(23):7345-55

Parsons SA, Millay DP, Wilkins BJ, Bueno OF, Tsika GL, Neilson JR, Liberatore CM, Yutzey KE, Crabtree GR, Tsika RW, Molkentin JD. Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy.
J Biol Chem. 2004 Jun 18;279(25):26192-200.

Brand M, Ranish JA, Kummer NT, Hamilton J, Igarashi K, Francastel C, Chi TH, Crabtree GR, Aebersold R, Groudine M. Dynamic changes in transcription factor complexes during erythroid differentiation revealed by quantitative proteomics.
Nat Struct Mol Biol. 2004 Jan;11(1):73-80. PDF

Neilson JR, Winslow MM, Hur EM, Crabtree GR.
Calcineurin B1 is essential for positive but not negative selection during thymocyte development. Immunity. 2004 Mar;20(3):255-66.

Stankunas et al. Condtional Protein Alleles Using Knock-in Mice and a Chemical Inducer of Dimerization Mol Cell Dec 12, 1615-1624, 2003.HTML PDF

Graef I.A. et al Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons.Cell. 2003 May 30;113(5):657-70. HTML PDF

Chi et al. Sequential roles of Brg, the ATPase subunit of BAF chormatin remodeling complexes in thymocyte development. Immunity 2003, 169-182 HTML PDF

Chang CP, et al. Sonographic staging of the developmental status of mouse embryos in utero.Genesis. 2003 May;36(1):7-11. HTML

Olave I, et al Identification of a polymorphic, neuron-specific chromatin remodeling complex.Genes Dev. 2002 Oct 1;16(19):2509-17. HTML PDF

Sheridan et al. Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3.J Biol Chem. 2002 Dec 13;277(50):48664-76 HTML

Diehn M, et al .Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation.Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11796-801. HTML

Chi et al.Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.Nature. 2002 Jul 11;418(6894):195-9. HTML PDF

Bayle et. al. Hyperphenylalaninemia and impaired glucose tolerance in mice lacking the bifunctional DCoH gene.J Biol Chem. 2002 Aug 9;277(32):28884-91HTML

Rando OJ, et al. Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex.Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2824-9. HTML

Graef IA, et al. Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.Cell. 2001 Jun 29;105(7):863-75 HTML PDF

Biggar SR, and Crabtree GR. Cell signaling can direct either binary or graded transcriptional responses.EMBO J. 2001 Jun 15;20(12):3167-76 HTML PDF

Graef IA, et al. Evolutionary relationships among Rel domains indicate functional diversification by recombination.Proc Natl Acad Sci U S A. 2001 May 8;98(10):5740-5 HTML

Graef IA, et al. L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons.Nature. 1999 Oct 14;401(6754):703-8 HTML PDF

Aramburu J, Heitman J, Crabtree GR. Calcineurin: a central controller of signalling in eukaryotes.
EMBO Rep. 2004 Apr;5(4):343-8.

Winslow MM, et al. Calcium signalling in lymphocytes.Curr Opin Immunol. 2003 Jun;15(3):299-307. HTML

Rando OJ, et al. Second messenger control of chromatin remodeling. Nat Struct Biol. 2003 Feb;10(2):81-3. HTML

Olave IA, et al Nuclear actin and actin-related proteins in chromatin remodeling.
Annu Rev Biochem. 2002;71:755-81. HTML

Crabtree GR, Olson EN. NFAT signaling: choreographing the social lives of cells.
Cell. 2002 Apr;109 67-79. HTML PDF

Graef IA, et al. NFAT signaling in vertebrate development. Curr Opin Genet Dev. 2001 Oct;11(5):505-12 HTML

Chi TH, and Crabtree GR. Perspectives: signal transduction. Inositol phosphates in the nucleus.Science. 2002 Mar 17;287(5460):1937-9 HTML

Crabtree GR. Calcium, calcineurin, and the control of transcription.
J Biol Chem. 2001 Jan 26;276(4):2313-6. HTML

Stewart S, Crabtree GR. Transcription. Regulation of the regulators.
Nature. 2000 Nov 2;408(6808):46-7