The Crabtree Lab
We are interested in the role of epigenetic mechanisms in the development of the nervous system and also in cancer. We focus primarily on the role of an ATP-dependent chromatin remodeling complex called mSWI/SNF or BAF that is frequently mutated in cancer and neurodevelopmental diseases. We are also developing new techniques based on chemically induced proximity to explore and understand how these mechanisms relate to autism, speech disorders and intellectual disability.
Fulton SL, Wenderski W, Lepack AE, Eagle AL, Fanutza T, Bastle RM, Ramakrishnan A, Hays EC, Neal A, Bendl J, Farrelly LA, Al-Kachak A, Lyu Y, Cetin B, Chan JC, Tran TN, Neve RL, Roper RJ, Brennand KJ, Roussos P, Schimenti JC, Friedman AK, Shen L, Blitzer RD, Robison AJ, Crabtree GR, Maze I. Nat Commun. 2022 Oct 26;13(1):6384. doi: 10.1038/s41467-022-34200-0. PMID: 36289231 Free PMC article.
Ulicna L, Kimmey SC, Weber CM, Allard GM, Wang A, Bui NQ, Bendall SC, Crabtree GR, Bean GR, Van Rechem C. Cancer Res. 2022 Aug 16;82(16):2829-2837. doi: 10.1158/0008-5472.CAN-21-1360. PMID: 35749589 Free PMC article.