Crabtree Laboratory: Developmental Genetics, Chemical Biology, Signaling and Chromatin Regulation

Stanford

The Crabtree Lab
at Stanford University

Jerry Crabtree

The Crabtree Lab

We are interested in the role of epigenetic mechanisms in the development of the nervous system and also in cancer. We focus primarily on the role of an ATP-dependent chromatin remodeling complex called mSWI/SNF or BAF that is frequently mutated in cancer and neurodevelopmental diseases. We are also developing new techniques based on chemically induced proximity to explore and understand how these mechanisms relate to autism, speech disorders and intellectual disability.

Research

We are exploring the role of chromatin regulation in verebrate development using genetic, proteomic and genomic approaches in mice.

A general problem in signal transduction and transcription is the mechanism by which signals of different intensities are converted to different cell fates.

Popular Press

Presidental Award for 2014 to Andrew Yoo

Presidental Award for 2014 to Andrew Yoo

May 21, 2014

Cigal Kadoch Receives Forbes’ 30-under-30 Award

Cigal Kadoch Receives Forbes' 30-under-30 Award

Jan 10, 2014

Forbes

New Way to Build Stronger Bones

New Way to Build Stronger Bones

Oct 8, 2006

BBC News

Lilly Reports Sepsis Drug Passes Advanced Trials

Lilly Reports Sepsis Drug Passes Advanced Trials

May 10, 2006

NY Times

Publications

Hagihara H, Shoji H, Kuroiwa M, Graef IA, Crabtree GR, Nishi A, Miyakawa T. Mol Brain. 2022 Nov 22;15(1):94. doi: 10.1186/s13041-022-00981-0. PMID: 36414974 Free PMC article.

Fulton SL, Wenderski W, Lepack AE, Eagle AL, Fanutza T, Bastle RM, Ramakrishnan A, Hays EC, Neal A, Bendl J, Farrelly LA, Al-Kachak A, Lyu Y, Cetin B, Chan JC, Tran TN, Neve RL, Roper RJ, Brennand KJ, Roussos P, Schimenti JC, Friedman AK, Shen L, Blitzer RD, Robison AJ, Crabtree GR, Maze I. Nat Commun. 2022 Oct 26;13(1):6384. doi: 10.1038/s41467-022-34200-0. PMID: 36289231 Free PMC article.

Ulicna L, Kimmey SC, Weber CM, Allard GM, Wang A, Bui NQ, Bendall SC, Crabtree GR, Bean GR, Van Rechem C. Cancer Res. 2022 Aug 16;82(16):2829-2837. doi: 10.1158/0008-5472.CAN-21-1360. PMID: 35749589 Free PMC article.