Publications

Papers in Press

Increased ACTL6A Occupancy Within mSWI/SNF Chromatin Remodelers Drives Human Squamous Cell Carcinoma. Chiung-Ying Chang, Zohar Shipony, Ann Kuo, Kyle M. Loh, William J. Greenleaf, Gerald R. Crabtree. bioRxiv 2021.03.22.435873; doi: https://doi.org/10.1101/2021.03.22.435873

mSWI/SNF interacts with the ribosome and its inhibition/mutations alter translation and sensitize to mTOR/PI3K inhibitors. Livia Ulicna, Samuel C. Kimmey, Christopher M. Weber, Grace M. Allard, Sean C. Bedall, Gerald R. Crabtree, Gregory R. Bean, Capucine Van Rechem. bioRxiv 2021.05.10.443459; doi: https://doi.org/10.1101/2021.05.10.443459

mSWI/SNF promotes polycomb repression both directly and through genome-wide redistribution. Christopher M. Weber, Antonina Hafner, Simon M. G. Braun, Jacob G. Kirkland, Benjamin Z. Stanton, Alistair N. Boettiger, Gerald R. Crabtree. In press, Nature Molecular and Structural Biology

Publications

Braun SMG, Petrova R, Tang J, Krokhotin A, Miller EL, Tang Y, Panagiotakos G,Crabtree GR. BAF subunit switching regulates chromatin accessibility to controlcell cycle exit in the developing mammalian cortex. Genes Dev. 2021 Mar1;35(5-6):335-353. doi: 10.1101/gad.342345.120. Epub 2021 Feb 18. PMID:33602870; PMCID: PMC7919417.

Lo YH, Kolahi KS, Du Y, Chang CY, Krokhotin A, Nair A, Sobba WD, Karlsson K,Jones SJ, Longacre TA, Mah AT, Tercan B, Sockell A, Xu H, Seoane JA, Chen J,Shmulevich I, Weissman JS, Curtis C, Califano A, Fu H, Crabtree GR, Kuo CJ. ACRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer OrganoidModel Reveals Essential and Nonessential Modes of Oncogenic Transformation.Cancer Discov. 2021 Jan 15. doi: 10.1158/2159-8290.CD-20-1109. Epub ahead ofprint. PMID: 33451982.

Ni K, Ren J, Xu X, He Y, Finney R, Braun SMG, Hathaway NA, Crabtree GR,Muegge K. LSH mediates gene repression through macroH2A deposition. Nat Commun.2020 Nov 6;11(1):5647. doi: 10.1038/s41467-020-19159-0. PMID: 33159050; PMCID:PMC7648012.

Sood S, Weber CM, Hodges HC, Krokhotin A, Shalizi A, Crabtree GR. CHD8 dosageregulates transcription in pluripotency and early murine neural differentiation.Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22331-22340. doi:10.1073/pnas.1921963117. Epub 2020 Aug 24. PMID: 32839322; PMCID: PMC7486765.

Chory EJ, Kirkland JG, Chang CY, D’Andrea VD, Gourisankar S, Dykhuizen EC,Crabtree GR. Chemical Inhibitors of a Selective SWI/SNF Function Synergize withATR Inhibition in Cancer Cell Killing. ACS Chem Biol. 2020 Jun19;15(6):1685-1696. doi: 10.1021/acschembio.0c00312. Epub 2020 May 27. PMID:32369697.

Wenderski W, Wang L, Krokhotin A, Walsh JJ, Li H, Shoji H, Ghosh S, GeorgeRD, Miller EL, Elias L, Gillespie MA, Son EY, Staahl BT, Baek ST, Stanley V,Moncada C, Shipony Z, Linker SB, Marchetto MCN, Gage FH, Chen D, Sultan T, ZakiMS, Ranish JA, Miyakawa T, Luo L, Malenka RC, Crabtree GR, Gleeson JG. Loss ofthe neural-specific BAF subunit ACTL6B relieves repression of early responsegenes and causes recessive autism. Proc Natl Acad Sci U S A. 2020 May5;117(18):10055-10066. doi: 10.1073/pnas.1908238117. Epub 2020 Apr 20. PMID:32312822; PMCID: PMC7211998.

Seoane JA, Kirkland JG, Caswell-Jin JL, Crabtree GR, Curtis C. Chromatinregulators mediate anthracycline sensitivity in breast cancer. Nat Med. 2019Nov;25(11):1721-1727. doi: 10.1038/s41591-019-0638-5. Epub 2019 Nov 7. PMID:31700186; PMCID: PMC7220800.

Chory EJ, Calarco JP, Hathaway NA, Bell O, Neel DS, Crabtree GR. NucleosomeTurnover Regulates Histone Methylation Patterns over the Genome. Mol Cell. 2019Jan 3;73(1):61-72.e3. doi: 10.1016/j.molcel.2018.10.028. Epub 2018 Nov 21. PMID:30472189; PMCID: PMC6510544.

Emmel EA, Verweij CL, Durand DB, Higgins KM, Lacy E, Crabtree GR. PillarsArticle: Cyclosporin A Specifically Inhibits Function of Nuclear ProteinsInvolved in T Cell Activation. Science. 1989. 246: 1617-1620. J Immunol.2018 Dec 1;201(11):3149-3152. PMID: 30455370.

Marian CA, Stoszko M, Wang L, Leighty MW, de Crignis E, Maschinot CA,Gatchalian J, Carter BC, Chowdhury B, Hargreaves DC, Duvall JR, Crabtree GR,Mahmoudi T, Dykhuizen EC. Small Molecule Targeting of Specific BAF (mSWI/SNF)Complexes for HIV Latency Reversal. Cell Chem Biol. 2018 Dec20;25(12):1443-1455.e14. doi: 10.1016/j.chembiol.2018.08.004. Epub 2018 Sep 6.PMID: 30197195; PMCID: PMC6404985.

Stanton BZ, Chory EJ, Crabtree GR. Chemically induced proximity in biologyand medicine. Science. 2018 Mar 9;359(6380):eaao5902. doi:10.1126/science.aao5902. PMID: 29590011; PMCID: PMC6417506.

Koh AS, Miller EL, Buenrostro JD, Moskowitz DM, Wang J, Greenleaf WJ, ChangHY, Crabtree GR. Rapid chromatin repression by Aire provides precise control ofimmune tolerance. Nat Immunol. 2018 Feb;19(2):162-172. doi:10.1038/s41590-017-0032-8. Epub 2018 Jan 15. PMID: 29335648; PMCID: PMC6049828.

Hodges HC, Stanton BZ, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL,Veverka V, Zhao K, Crabtree GR. Dominant-negative SMARCA4 mutants alter theaccessibility landscape of tissue-unrestricted enhancers. Nat Struct Mol Biol.2018 Jan;25(1):61-72. doi: 10.1038/s41594-017-0007-3. Epub 2017 Dec 11. PMID:29323272; PMCID: PMC5909405.

Braun SMG, Kirkland JG, Chory EJ, Husmann D, Calarco JP, Crabtree GR. Rapidand reversible epigenome editing by endogenous chromatin regulators. Nat Commun.2017 Sep 15;8(1):560. doi: 10.1038/s41467-017-00644-y. PMID: 28916764; PMCID:PMC5601922.

Morrison EA, Sanchez JC, Ronan JL, Farrell DP, Varzavand K, Johnson JK, GuBX, Crabtree GR, Musselman CA. DNA binding drives the association of BRG1/hBRMbromodomains with nucleosomes. Nat Commun. 2017 Jul 14;8:16080. doi:10.1038/ncomms16080. PMID: 28706277; PMCID: PMC5519978.

Ren J, Hathaway NA, Crabtree GR, Muegge K. Tethering of Lsh at the Oct4locus promotes gene repression associated with epigenetic changes. Epigenetics.2018;13(2):173-181. doi: 10.1080/15592294.2017.1338234. Epub 2018 Feb 6. PMID:28621576; PMCID: PMC5873361.

Platt RJ, Zhou Y, Slaymaker IM, Shetty AS, Weisbach NR, Kim JA, Sharma J,Desai M, Sood S, Kempton HR, Crabtree GR, Feng G, Zhang F. Chd8 Mutation Leadsto Autistic-like Behaviors and Impaired Striatal Circuits. Cell Rep. 2017 Apr11;19(2):335-350. doi: 10.1016/j.celrep.2017.03.052. PMID: 28402856; PMCID:PMC5455342.

Stanton BZ, Hodges C, Crabtree GR, Zhao K. A General Non-Radioactive ATPaseAssay for Chromatin Remodeling Complexes. Curr Protoc Chem Biol. 2017 Mar2;9(1):1-10. doi: 10.1002/cpch.16. PMID: 28253434; PMCID: PMC5334659.

Miller EL, Hargreaves DC, Kadoch C, Chang CY, Calarco JP, Hodges C,Buenrostro JD, Cui K, Greenleaf WJ, Zhao K, Crabtree GR. TOP2 synergizes withBAF chromatin remodeling for both resolution and formation of facultativeheterochromatin. Nat Struct Mol Biol. 2017 Apr;24(4):344-352. doi:10.1038/nsmb.3384. Epub 2017 Feb 27. PMID: 28250416; PMCID: PMC5395302.

Kadoch C, Williams RT, Calarco JP, Miller EL, Weber CM, Braun SM, Pulice JL,Chory EJ, Crabtree GR. Dynamics of BAF-Polycomb complex opposition onheterochromatin in normal and oncogenic states. Nat Genet. 2017Feb;49(2):213-222. doi: 10.1038/ng.3734. Epub 2016 Dec 12. PMID: 27941796;PMCID: PMC5285326.

Stanton BZ, Hodges C, Calarco JP, Braun SM, Ku WL, Kadoch C, Zhao K,Crabtree GR. Smarca4 ATPase mutations disrupt direct eviction of PRC1 fromchromatin. Nat Genet. 2017 Feb;49(2):282-288. doi: 10.1038/ng.3735. Epub 2016Dec 12. PMID: 27941795; PMCID: PMC5373480.

Krasteva V, Crabtree GR, Lessard JA. The BAF45a/PHF10 subunit of SWI/SNF-like chromatin remodeling complexes is essential for hematopoietic stem cellmaintenance. Exp Hematol. 2017 Apr;48:58-71.e15. doi:10.1016/j.exphem.2016.11.008. Epub 2016 Dec 5. PMID: 27931852.

Hodges C, Kirkland JG, Crabtree GR. The Many Roles of BAF (mSWI/SNF) andPBAF Complexes in Cancer. Cold Spring Harb Perspect Med. 2016 Aug1;6(8):a026930. doi: 10.1101/cshperspect.a026930. PMID: 27413115; PMCID:PMC4968166.

Kadoch C, Crabtree GR. Mammalian SWI/SNF chromatin remodeling complexes andcancer: Mechanistic insights gained from human genomics. Sci Adv. 2015 Jun12;1(5):e1500447. doi: 10.1126/sciadv.1500447. PMID: 26601204; PMCID:PMC4640607.

Zhan X, Cao M, Yoo AS, Zhang Z, Chen L, Crabtree GR, Wu JI. Generation ofBAF53b-Cre transgenic mice with pan-neuronal Cre activities. Genesis. 2015Jul;53(7):440-8. doi: 10.1002/dvg.22866. Epub 2015 Jun 23. PMID: 26077106;PMCID: PMC4514543.

Son EY, Crabtree GR. The role of BAF (mSWI/SNF) complexes in mammalianneural development. Am J Med Genet C Semin Med Genet. 2014 Sep;166C(3):333-49.doi: 10.1002/ajmg.c.31416. Epub 2014 Sep 5. PMID: 25195934; PMCID: PMC4405377.

Buscarlet M, Krasteva V, Ho L, Simon C, Hébert J, Wilhelm B, Crabtree GR,Sauvageau G, Thibault P, Lessard JA. Essential role of BRG, the ATPase subunitof BAF chromatin remodeling complexes, in leukemia maintenance. Blood. 2014 Mar13;123(11):1720-8. doi: 10.1182/blood-2013-02-483495. Epub 2014 Jan 29. PMID:24478402; PMCID: PMC3954053.

Takebayashi S, Lei I, Ryba T, Sasaki T, Dileep V, Battaglia D, Gao X, FangP, Fan Y, Esteban MA, Tang J, Crabtree GR, Wang Z, Gilbert DM. Murine esBAFchromatin remodeling complex subunits BAF250a and Brg1 are necessary to maintainand reprogram pluripotency-specific replication timing of select replicationdomains. Epigenetics Chromatin. 2013 Dec 13;6(1):42. doi:10.1186/1756-8935-6-42. PMID: 24330833; PMCID: PMC3895691.

Staahl BT, Crabtree GR. Creating a neural specific chromatin landscape bynpBAF and nBAF complexes. Curr Opin Neurobiol. 2013 Dec;23(6):903-13. doi:10.1016/j.conb.2013.09.003. Epub 2013 Oct 1. PMID: 24090879; PMCID: PMC3878911.

Tang J, Yoo AS, Crabtree GR. Reprogramming human fibroblasts to neurons byrecapitulating an essential microRNA-chromatin switch. Curr Opin Genet Dev. 2013Oct;23(5):591-8. doi: 10.1016/j.gde.2013.07.001. PMID: 24035011; PMCID:PMC3951511.

Staahl BT, Tang J, Wu W, Sun A, Gitler AD, Yoo AS, Crabtree GR. Kineticanalysis of npBAF to nBAF switching reveals exchange of SS18 with CREST andintegration with neural developmental pathways. J Neurosci. 2013 Jun19;33(25):10348-61. doi: 10.1523/JNEUROSCI.1258-13.2013. PMID: 23785148; PMCID:PMC3685834.

Chesi A, Staahl BT, Jovičić A, Couthouis J, Fasolino M, Raphael AR, YamazakiT, Elias L, Polak M, Kelly C, Williams KL, Fifita JA, Maragakis NJ, NicholsonGA, King OD, Reed R, Crabtree GR, Blair IP, Glass JD, Gitler AD. Exomesequencing to identify de novo mutations in sporadic ALS trios. Nat Neurosci.2013 Jul;16(7):851-5. doi: 10.1038/nn.3412. Epub 2013 May 26. PMID: 23708140;PMCID: PMC3709464.

Dykhuizen EC, Hargreaves DC, Miller EL, Cui K, Korshunov A, Kool M, PfisterS, Cho YJ, Zhao K, Crabtree GR. BAF complexes facilitate decatenation of DNA bytopoisomerase IIα. Nature. 2013 May 30;497(7451):624-7. doi:10.1038/nature12146. Epub 2013 May 22. PMID: 23698369; PMCID: PMC3668793.

Kadoch C, Hargreaves DC, Hodges C, Elias L, Ho L, Ranish J, Crabtree GR.Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifiesextensive roles in human malignancy. Nat Genet. 2013 Jun;45(6):592-601. doi:10.1038/ng.2628. Epub 2013 May 5. PMID: 23644491; PMCID: PMC3667980.

Ronan JL, Wu W, Crabtree GR. From neural development to cognition:unexpected roles for chromatin. Nat Rev Genet. 2013 May;14(5):347-59. doi:10.1038/nrg3413. Epub 2013 Apr 9. Erratum in: Nat Rev Genet. 2013 Jun;14(6):440.PMID: 23568486; PMCID: PMC4010428.

Kadoch C, Crabtree GR. Reversible disruption of mSWI/SNF (BAF) complexes bythe SS18-SSX oncogenic fusion in synovial sarcoma. Cell. 2013 Mar28;153(1):71-85. doi: 10.1016/j.cell.2013.02.036. PMID: 23540691; PMCID:PMC3655887.

Vogel-Ciernia A, Matheos DP, Barrett RM, Kramár EA, Azzawi S, Chen Y, MagnanCN, Zeller M, Sylvain A, Haettig J, Jia Y, Tran A, Dang R, Post RJ, Chabrier M,Babayan AH, Wu JI, Crabtree GR, Baldi P, Baram TZ, Lynch G, Wood MA. The neuron-specific chromatin regulatory subunit BAF53b is necessary for synapticplasticity and memory. Nat Neurosci. 2013 May;16(5):552-61. doi:10.1038/nn.3359. Epub 2013 Mar 24. PMID: 23525042; PMCID: PMC3777648.

Crabtree GR. Rethinking our intellectual origins: response to Kalinka et al.Trends Genet. 2013 Mar;29(3):127-9. doi: 10.1016/j.tig.2013.01.013. Epub 2013Feb 17. PMID: 23422050.

Bao X, Tang J, Lopez-Pajares V, Tao S, Qu K, Crabtree GR, Khavari PA. ACTL6aenforces the epidermal progenitor state by suppressing SWI/SNF-dependentinduction of KLF4. Cell Stem Cell. 2013 Feb 7;12(2):193-203. doi:10.1016/j.stem.2012.12.014. PMID: 23395444; PMCID: PMC3661004.

Sun AX, Crabtree GR, Yoo AS. MicroRNAs: regulators of neuronal fate. CurrOpin Cell Biol. 2013 Apr;25(2):215-21. doi: 10.1016/j.ceb.2012.12.007. Epub 2013Jan 29. PMID: 23374323; PMCID: PMC3836262.

Crabtree GR. Our fragile intellect. Part II. Trends Genet. 2013Jan;29(1):3-5. doi: 10.1016/j.tig.2012.10.003. Epub 2012 Nov 12. PMID: 23153597.

Crabtree GR. Our fragile intellect. Part I. Trends Genet. 2013Jan;29(1):1-3. doi: 10.1016/j.tig.2012.10.002. Epub 2012 Nov 12. PMID: 23153596.

Krasteva V, Buscarlet M, Diaz-Tellez A, Bernard MA, Crabtree GR, Lessard JA.The BAF53a subunit of SWI/SNF-like BAF complexes is essential for hemopoieticstem cell function. Blood. 2012 Dec 6;120(24):4720-32. doi:10.1182/blood-2012-04-427047. Epub 2012 Sep 26. PMID: 23018638.

Dykhuizen EC, Carmody LC, Tolliday N, Crabtree GR, Palmer MA. Screening forinhibitors of an essential chromatin remodeler in mouse embryonic stem cells bymonitoring transcriptional regulation. J Biomol Screen. 2012 Oct;17(9):1221-30.doi: 10.1177/1087057112455060. Epub 2012 Aug 1. PMID: 22853929; PMCID:PMC4097195.

Hodges C, Crabtree GR. Dynamics of inherently bounded histone modificationdomains. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13296-301. doi:10.1073/pnas.1211172109. Epub 2012 Jul 30. PMID: 22847427; PMCID: PMC3421184.

Pugh TJ, Weeraratne SD, Archer TC, Pomeranz Krummel DA, Auclair D,Bochicchio J, Carneiro MO, Carter SL, Cibulskis K, Erlich RL, Greulich H,Lawrence MS, Lennon NJ, McKenna A, Meldrim J, Ramos AH, Ross MG, Russ C, SheflerE, Sivachenko A, Sogoloff B, Stojanov P, Tamayo P, Mesirov JP, Amani V, TeiderN, Sengupta S, Francois JP, Northcott PA, Taylor MD, Yu F, Crabtree GR, KautzmanAG, Gabriel SB, Getz G, Jäger N, Jones DT, Lichter P, Pfister SM, Roberts TM,Meyerson M, Pomeroy SL, Cho YJ. Medulloblastoma exome sequencing uncoverssubtype-specific somatic mutations. Nature. 2012 Aug 2;488(7409):106-10. doi:10.1038/nature11329. PMID: 22820256; PMCID: PMC3413789.

Goodyer WR, Gu X, Liu Y, Bottino R, Crabtree GR, Kim SK. Neonatal β celldevelopment in mice and humans is regulated by calcineurin/NFAT. Dev Cell. 2012Jul 17;23(1):21-34. doi: 10.1016/j.devcel.2012.05.014. PMID: 22814600; PMCID:PMC3587727.

Hathaway NA, Bell O, Hodges C, Miller EL, Neel DS, Crabtree GR. Dynamics andmemory of heterochromatin in living cells. Cell. 2012 Jun 22;149(7):1447-60.doi: 10.1016/j.cell.2012.03.052. Epub 2012 Jun 14. PMID: 22704655; PMCID:PMC3422694.

Ho L, Miller EL, Ronan JL, Ho WQ, Jothi R, Crabtree GR. esBAF facilitatespluripotency by conditioning the genome for LIF/STAT3 signalling and byregulating polycomb function. Nat Cell Biol. 2011 Jul 24;13(8):903-13. doi:10.1038/ncb2285. PMID: 21785422; PMCID: PMC3155811.

Yoo AS, Sun AX, Li L, Shcheglovitov A, Portmann T, Li Y, Lee-Messer C,Dolmetsch RE, Tsien RW, Crabtree GR. MicroRNA-mediated conversion of humanfibroblasts to neurons. Nature. 2011 Jul 13;476(7359):228-31. doi:10.1038/nature10323. PMID: 21753754; PMCID: PMC3348862.

Liang FS, Ho WQ, Crabtree GR. Engineering the ABA plant stress pathway forregulation of induced proximity. Sci Signal. 2011 Mar 15;4(164):rs2. doi:10.1126/scisignal.2001449. PMID: 21406691; PMCID: PMC3110149.

Hargreaves DC, Crabtree GR. ATP-dependent chromatin remodeling: genetics,genomics and mechanisms. Cell Res. 2011 Mar;21(3):396-420. doi:10.1038/cr.2011.32. Epub 2011 Mar 1. PMID: 21358755; PMCID: PMC3110148.

Shaw JP, Utz PJ, Durand DB, Toole JJ, Emmel EA, Crabtree GR. Identificationof a putative regulator of early T cell activation genes. Science. 1988. 241:202-205. J Immunol. 2010 Nov 1;185(9):4972-5. PMID: 20962265.

Lessard JA, Crabtree GR. Chromatin regulatory mechanisms in pluripotency.Annu Rev Cell Dev Biol. 2010;26:503-32. doi: 10.1146/annurev-cellbio-051809-102012. PMID: 20624054; PMCID: PMC3085914.

Ho L, Crabtree GR. Chromatin remodelling during development. Nature. 2010Jan 28;463(7280):474-84. doi: 10.1038/nature08911. PMID: 20110991; PMCID:PMC3060774.

Crabtree GR, Schreiber SL. SnapShot: Ca2+-calcineurin-NFAT signaling. Cell.2009 Jul 10;138(1):210, 210.e1. doi: 10.1016/j.cell.2009.06.026. PMID: 19596245;PMCID: PMC2958059.

Yoo AS, Staahl BT, Chen L, Crabtree GR. MicroRNA-mediated switching ofchromatin-remodelling complexes in neural development. Nature. 2009 Jul30;460(7255):642-6. doi: 10.1038/nature08139. Epub 2009 Jun 28. Erratum in:Nature. 2009 Sep 10;461(7261):296. PMID: 19561591; PMCID: PMC2921580.

Liang FS, Crabtree GR. Developmental biology: The early heart remodelled.Nature. 2009 Jun 4;459(7247):654-5. doi: 10.1038/459654a. PMID: 19494907; PMCID:PMC3027553.

Yoo AS, Crabtree GR. ATP-dependent chromatin remodeling in neuraldevelopment. Curr Opin Neurobiol. 2009 Apr;19(2):120-6. doi:10.1016/j.conb.2009.04.006. Epub 2009 May 11. PMID: 19442513; PMCID: PMC2756292.

Ho L, Ronan JL, Wu J, Staahl BT, Chen L, Kuo A, Lessard J, Nesvizhskii AI,Ranish J, Crabtree GR. An embryonic stem cell chromatin remodeling complex,esBAF, is essential for embryonic stem cell self-renewal and pluripotency. ProcNatl Acad Sci U S A. 2009 Mar 31;106(13):5181-6. doi: 10.1073/pnas.0812889106.Epub 2009 Mar 11. PMID: 19279220; PMCID: PMC2654396.

Ho L, Jothi R, Ronan JL, Cui K, Zhao K, Crabtree GR. An embryonic stem cellchromatin remodeling complex, esBAF, is an essential component of the corepluripotency transcriptional network. Proc Natl Acad Sci U S A. 2009 Mar31;106(13):5187-91. doi: 10.1073/pnas.0812888106. Epub 2009 Mar 11. PMID:19279218; PMCID: PMC2654397.

Kao SC, Wu H, Xie J, Chang CP, Ranish JA, Graef IA, Crabtree GR.Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann celldifferentiation. Science. 2009 Jan 30;323(5914):651-4. doi:10.1126/science.1166562. PMID: 19179536; PMCID: PMC2790385.

Lazarevic V, Zullo AJ, Schweitzer MN, Staton TL, Gallo EM, Crabtree GR,Glimcher LH. The gene encoding early growth response 2, a target of thetranscription factor NFAT, is required for the development and maturation ofnatural killer T cells. Nat Immunol. 2009 Mar;10(3):306-13. doi:10.1038/ni.1696. Epub 2009 Jan 25. PMID: 19169262; PMCID: PMC2728767.

Wu JI, Lessard J, Crabtree GR. Understanding the words of chromatinregulation. Cell. 2009 Jan 23;136(2):200-6. doi: 10.1016/j.cell.2009.01.009.PMID: 19167321; PMCID: PMC2770578.

Marinec PS, Chen L, Barr KJ, Mutz MW, Crabtree GR, Gestwicki JE.FK506-binding protein (FKBP) partitions a modified HIV protease inhibitor intoblood cells and prolongs its lifetime in vivo. Proc Natl Acad Sci U S A. 2009Feb 3;106(5):1336-41. doi: 10.1073/pnas.0805375106. Epub 2009 Jan 21. PMID:19164520; PMCID: PMC2635806.

Crabtree GR, Graef IA. Bursting into the nucleus. Sci Signal. 2008 Dec23;1(51):pe54. doi: 10.1126/scisignal.151pe54. PMID: 19109237; PMCID:PMC2713346.

Ho L, Crabtree GR. An EZ mark to miss. Cell Stem Cell. 2008 Dec4;3(6):577-8. doi: 10.1016/j.stem.2008.11.007. PMID: 19041770; PMCID:PMC2704610.

Li DH, Winslow MM, Cao TM, Chen AH, Davis CR, Mellins ED, Utz PJ, CrabtreeGR, Parnes JR. Modulation of peripheral B cell tolerance by CD72 in a murinemodel. Arthritis Rheum. 2008 Oct;58(10):3192-204. doi: 10.1002/art.23812. PMID:18821699; PMCID: PMC2790383.

Gallo EM, Ho L, Winslow MM, Staton TL, Crabtree GR. Selective role ofcalcineurin in haematopoiesis and lymphopoiesis. EMBO Rep. 2008Nov;9(11):1141-8. doi: 10.1038/embor.2008.174. Epub 2008 Sep 26. PMID: 18818667;PMCID: PMC2581854.

Radermacher AN, Crabtree GR. Monster protein controls calcium entry andfights infection. Immunity. 2008 Jan;28(1):13-4. doi:10.1016/j.immuni.2007.12.009. PMID: 18199413.

Gallo EM, Winslow MM, Canté-Barrett K, Radermacher AN, Ho L, McGinnis L,Iritani B, Neilson JR, Crabtree GR. Calcineurin sets the bandwidth fordiscrimination of signals during thymocyte development. Nature. 2007 Nov29;450(7170):731-5. doi: 10.1038/nature06305. PMID: 18046413; PMCID: PMC5336393.

Wu JI, Lessard J, Olave IA, Qiu Z, Ghosh A, Graef IA, Crabtree GR.Regulation of dendritic development by neuron-specific chromatin remodelingcomplexes. Neuron. 2007 Oct 4;56(1):94-108. doi: 10.1016/j.neuron.2007.08.021.PMID: 17920018.

Wu H, Kao SC, Barrientos T, Baldwin SH, Olson EN, Crabtree GR, Zhou B, ChangCP. Down syndrome critical region-1 is a transcriptional target of nuclearfactor of activated T cells-c1 within the endocardium during heart development.J Biol Chem. 2007 Oct 19;282(42):30673-9. doi: 10.1074/jbc.M703622200. Epub 2007Aug 10. PMID: 17693409; PMCID: PMC2366997.

Lessard J, Wu JI, Ranish JA, Wan M, Winslow MM, Staahl BT, Wu H, AebersoldR, Graef IA, Crabtree GR. An essential switch in subunit composition of achromatin remodeling complex during neural development. Neuron. 2007 Jul19;55(2):201-15. doi: 10.1016/j.neuron.2007.06.019. PMID: 17640523; PMCID:PMC2674110.

Stankunas K, Crabtree GR. Exploiting protein destruction for constructiveuse. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11511-2. doi:10.1073/pnas.0704762104. Epub 2007 Jul 2. PMID: 17606901; PMCID: PMC1913851.

Davies KJ, Ermak G, Rothermel BA, Pritchard M, Heitman J, Ahnn J, Henrique-Silva F, Crawford D, Canaider S, Strippoli P, Carinci P, Min KT, Fox DS,Cunningham KW, Bassel-Duby R, Olson EN, Zhang Z, Williams RS, Gerber HP, Pérez-Riba M, Seo H, Cao X, Klee CB, Redondo JM, Maltais LJ, Bruford EA, Povey S,Molkentin JD, McKeon FD, Duh EJ, Crabtree GR, Cyert MS, de la Luna S, EstivillX. Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.FASEB J. 2007 Oct;21(12):3023-8. doi: 10.1096/fj.06-7246com. Epub 2007 Jun 26.PMID: 17595344.

Wu JI, Crabtree GR. Cell signaling. Nuclear actin as choreographer of cellmorphology and transcription. Science. 2007 Jun 22;316(5832):1710-1. doi:10.1126/science.1145014. Erratum in: Science. 2007 Sep 21;317(5845):1682.Crabtee, Gerald R [corrected to Crabtree, Gerald R]. PMID: 17588921.

Canté-Barrett K, Winslow MM, Crabtree GR. Selective role of NFATc3 inpositive selection of thymocytes. J Immunol. 2007 Jul 1;179(1):103-10. doi:10.4049/jimmunol.179.1.103. PMID: 17579027.

Stankunas K, Bayle JH, Havranek JJ, Wandless TJ, Baker D, Crabtree GR,Gestwicki JE. Rescue of degradation-prone mutants of the FK506-rapamycin binding(FRB) protein with chemical ligands. Chembiochem. 2007 Jul 9;8(10):1162-9. doi:10.1002/cbic.200700087. PMID: 17525916.

Wu H, Peisley A, Graef IA, Crabtree GR. NFAT signaling and the invention ofvertebrates. Trends Cell Biol. 2007 Jun;17(6):251-60. doi:10.1016/j.tcb.2007.04.006. Epub 2007 May 10. PMID: 17493814.

Sellmyer MA, Stankunas K, Briesewitz R, Crabtree GR, Wandless TJ.Engineering small molecule specificity in nearly identical cellularenvironments. Bioorg Med Chem Lett. 2007 May 15;17(10):2703-5. doi:10.1016/j.bmcl.2007.03.012. Epub 2007 Mar 12. PMID: 17383876; PMCID: PMC1949043.

Pan M, Winslow MM, Chen L, Kuo A, Felsher D, Crabtree GR. Enhanced NFATc1nuclear occupancy causes T cell activation independent of CD28 costimulation. JImmunol. 2007 Apr 1;178(7):4315-21. doi: 10.4049/jimmunol.178.7.4315. PMID:17371988.

Liu KJ, Arron JR, Stankunas K, Crabtree GR, Longaker MT. Chemical rescue ofcleft palate and midline defects in conditional GSK-3beta mice. Nature. 2007 Mar1;446(7131):79-82. doi: 10.1038/nature05557. Epub 2007 Feb 11. PMID: 17293880.

Davé V, Childs T, Xu Y, Ikegami M, Besnard V, Maeda Y, Wert SE, Neilson JR,Crabtree GR, Whitsett JA. Calcineurin/Nfat signaling is required for perinatallung maturation and function. J Clin Invest. 2006 Oct;116(10):2597-609. doi:10.1172/JCI27331. Epub 2006 Sep 21. PMID: 16998587; PMCID: PMC1570374.

Heit JJ, Apelqvist AA, Gu X, Winslow MM, Neilson JR, Crabtree GR, Kim SK.Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function.Nature. 2006 Sep 21;443(7109):345-9. doi: 10.1038/nature05097. PMID: 16988714.

Yang TT, Suk HY, Yang X, Olabisi O, Yu RY, Durand J, Jelicks LA, Kim JY,Scherer PE, Wang Y, Feng Y, Rossetti L, Graef IA, Crabtree GR, Chow CW. Role oftranscription factor NFAT in glucose and insulin homeostasis. Mol Cell Biol.2006 Oct;26(20):7372-87. doi: 10.1128/MCB.00580-06. Epub 2006 Aug 14. PMID:16908540; PMCID: PMC1636854.

Winslow MM, Pan M, Starbuck M, Gallo EM, Deng L, Karsenty G, Crabtree GR.Calcineurin/NFAT signaling in osteoblasts regulates bone mass. Dev Cell. 2006Jun;10(6):771-82. doi: 10.1016/j.devcel.2006.04.006. PMID: 16740479.

Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR, Chen L,Heit JJ, Kim SK, Yamasaki N, Miyakawa T, Francke U, Graef IA, Crabtree GR. NFATdysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature.2006 Jun 1;441(7093):595-600. doi: 10.1038/nature04678. Epub 2006 Mar 22. PMID:16554754.

Winslow MM, Gallo EM, Neilson JR, Crabtree GR. The calcineurin phosphatasecomplex modulates immunogenic B cell responses. Immunity. 2006 Feb;24(2):141-52.doi: 10.1016/j.immuni.2005.12.013. PMID: 16473827.

Canté-Barrett K, Gallo EM, Winslow MM, Crabtree GR. Thymocyte negativeselection is mediated by protein kinase C- and Ca2+-dependent transcriptionalinduction of bim [corrected]. J Immunol. 2006 Feb 15;176(4):2299-306. doi:10.4049/jimmunol.176.4.2299. Erratum in: J Immunol. 2006 Mar 15;176(6):3843.PMID: 16455986.

Bayle JH, Grimley JS, Stankunas K, Gestwicki JE, Wandless TJ, Crabtree GR.Rapamycin analogs with differential binding specificity permit orthogonalcontrol of protein activity. Chem Biol. 2006 Jan;13(1):99-107. doi:10.1016/j.chembiol.2005.10.017. PMID: 16426976.

Gallo EM, Canté-Barrett K, Crabtree GR. Lymphocyte calcium signaling frommembrane to nucleus. Nat Immunol. 2006 Jan;7(1):25-32. doi: 10.1038/ni1295.PMID: 16357855.

Bose M, Gestwicki JE, Devasthali V, Crabtree GR, Graef IA. ‘Nature-inspired’drug-protein complexes as inhibitors of Abeta aggregation. Biochem Soc Trans.2005 Aug;33(Pt 4):543-7. doi: 10.1042/BST0330543. PMID: 16042540.

Mammucari C, Tommasi di Vignano A, Sharov AA, Neilson J, Havrda MC, Roop DR,Botchkarev VA, Crabtree GR, Dotto GP. Integration of Notch 1 andcalcineurin/NFAT signaling pathways in keratinocyte growth and differentiationcontrol. Dev Cell. 2005 May;8(5):665-76. doi: 10.1016/j.devcel.2005.02.016.PMID: 15866158.

Yang TT, Xiong Q, Graef IA, Crabtree GR, Chow CW. Recruitment of theextracellular signal-regulated kinase/ribosomal S6 kinase signaling pathway tothe NFATc4 transcription activation complex. Mol Cell Biol. 2005Feb;25(3):907-20. doi: 10.1128/MCB.25.3.907-920.2005. PMID: 15657420; PMCID:PMC544015.

Winslow MM, Crabtree GR. Immunology. Decoding calcium signaling. Science.2005 Jan 7;307(5706):56-7. doi: 10.1126/science.1108163. PMID: 15637261.

Liston A, Lesage S, Gray DH, O’Reilly LA, Strasser A, Fahrer AM, Boyd RL,Wilson J, Baxter AG, Gallo EM, Crabtree GR, Peng K, Wilson SR, Goodnow CC.Generalized resistance to thymic deletion in the NOD mouse; a polygenic traitcharacterized by defective induction of Bim. Immunity. 2004 Dec;21(6):817-30.doi: 10.1016/j.immuni.2004.10.014. PMID: 15589170.

Gestwicki JE, Crabtree GR, Graef IA. Harnessing chaperones to generatesmall-molecule inhibitors of amyloid beta aggregation. Science. 2004 Oct29;306(5697):865-9. doi: 10.1126/science.1101262. PMID: 15514157.

Chang CP, Neilson JR, Bayle JH, Gestwicki JE, Kuo A, Stankunas K, Graef IA,Crabtree GR. A field of myocardial-endocardial NFAT signaling underlies heartvalve morphogenesis. Cell. 2004 Sep 3;118(5):649-63. doi:10.1016/j.cell.2004.08.010. PMID: 15339668.

Rose RB, Pullen KE, Bayle JH, Crabtree GR, Alber T. Biochemical andstructural basis for partially redundant enzymatic and transcriptional functionsof DCoH and DCoH2. Biochemistry. 2004 Jun 15;43(23):7345-55. doi:10.1021/bi049620t. PMID: 15182178.

Parsons SA, Millay DP, Wilkins BJ, Bueno OF, Tsika GL, Neilson JR,Liberatore CM, Yutzey KE, Crabtree GR, Tsika RW, Molkentin JD. Genetic loss ofcalcineurin blocks mechanical overload-induced skeletal muscle fiber typeswitching but not hypertrophy. J Biol Chem. 2004 Jun 18;279(25):26192-200. doi:10.1074/jbc.M313800200. Epub 2004 Apr 13. PMID: 15082723.

Aramburu J, Heitman J, Crabtree GR. Calcineurin: a central controller ofsignalling in eukaryotes. EMBO Rep. 2004 Apr;5(4):343-8. doi:10.1038/sj.embor.7400133. PMID: 15060569; PMCID: PMC1299038.

Chang CP, McDill BW, Neilson JR, Joist HE, Epstein JA, Crabtree GR, Chen F.Calcineurin is required in urinary tract mesenchyme for the development of thepyeloureteral peristaltic machinery. J Clin Invest. 2004 Apr;113(7):1051-8. doi:10.1172/JCI20049. PMID: 15057312; PMCID: PMC379320.

Neilson JR, Winslow MM, Hur EM, Crabtree GR. Calcineurin B1 is essentialfor positive but not negative selection during thymocyte development. Immunity.2004 Mar;20(3):255-66. doi: 10.1016/s1074-7613(04)00052-4. PMID: 15030770.

Brand M, Ranish JA, Kummer NT, Hamilton J, Igarashi K, Francastel C, ChiTH, Crabtree GR, Aebersold R, Groudine M. Dynamic changes in transcriptionfactor complexes during erythroid differentiation revealed by quantitativeproteomics. Nat Struct Mol Biol. 2004 Jan;11(1):73-80. doi: 10.1038/nsmb713.Epub 2003 Dec 29. PMID: 14718926.

Stankunas K, Bayle JH, Gestwicki JE, Lin YM, Wandless TJ, Crabtree GR.Conditional protein alleles using knockin mice and a chemical inducer ofdimerization. Mol Cell. 2003 Dec;12(6):1615-24. doi:10.1016/s1097-2765(03)00491-x. PMID: 14690613.

Chi TH, Wan M, Lee PP, Akashi K, Metzger D, Chambon P, Wilson CB, CrabtreeGR. Sequential roles of Brg, the ATPase subunit of BAF chromatin remodelingcomplexes, in thymocyte development. Immunity. 2003 Aug;19(2):169-82. doi:10.1016/s1074-7613(03)00199-7. PMID: 12932351.

Winslow MM, Neilson JR, Crabtree GR. Calcium signalling in lymphocytes.Curr Opin Immunol. 2003 Jun;15(3):299-307. doi: 10.1016/s0952-7915(03)00050-5.PMID: 12787755.

Graef IA, Wang F, Charron F, Chen L, Neilson J, Tessier-Lavigne M, CrabtreeGR. Neurotrophins and netrins require calcineurin/NFAT signaling to stimulateoutgrowth of embryonic axons. Cell. 2003 May 30;113(5):657-70. doi:10.1016/s0092-8674(03)00390-8. PMID: 12787506.

Chang CP, Chen L, Crabtree GR. Sonographic staging of the developmentalstatus of mouse embryos in utero. Genesis. 2003 May;36(1):7-11. doi:10.1002/gene.10186. PMID: 12748962.

Rando OJ, Chi TH, Crabtree GR. Second messenger control of chromatinremodeling. Nat Struct Biol. 2003 Feb;10(2):81-3. doi: 10.1038/nsb0203-81. PMID:12555081.

Olave I, Wang W, Xue Y, Kuo A, Crabtree GR. Identification of apolymorphic, neuron-specific chromatin remodeling complex. Genes Dev. 2002 Oct1;16(19):2509-17. doi: 10.1101/gad.992102. PMID: 12368262; PMCID: PMC187451.

Sheridan CM, Heist EK, Beals CR, Crabtree GR, Gardner P. Protein kinase Anegatively modulates the nuclear accumulation of NF-ATc1 by priming forsubsequent phosphorylation by glycogen synthase kinase-3. J Biol Chem. 2002 Dec13;277(50):48664-76. doi: 10.1074/jbc.M207029200. Epub 2002 Sep 25. PMID:12351631.

Diehn M, Alizadeh AA, Rando OJ, Liu CL, Stankunas K, Botstein D, CrabtreeGR, Brown PO. Genomic expression programs and the integration of the CD28costimulatory signal in T cell activation. Proc Natl Acad Sci U S A. 2002 Sep3;99(18):11796-801. doi: 10.1073/pnas.092284399. Epub 2002 Aug 23. Erratum in:Proc Natl Acad Sci U S A 2002 Nov 12;99(23):15245. PMID: 12195013; PMCID:PMC129348.

Chi TH, Wan M, Zhao K, Taniuchi I, Chen L, Littman DR, Crabtree GR.Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.Nature. 2002 Jul 11;418(6894):195-9. doi: 10.1038/nature00876. PMID: 12110891.

Olave IA, Reck-Peterson SL, Crabtree GR. Nuclear actin and actin-relatedproteins in chromatin remodeling. Annu Rev Biochem. 2002;71:755-81. doi:10.1146/annurev.biochem.71.110601.135507. Epub 2001 Nov 9. PMID: 12045110.

Bayle JH, Randazzo F, Johnen G, Kaufman S, Nagy A, Rossant J, Crabtree GR.Hyperphenylalaninemia and impaired glucose tolerance in mice lacking thebifunctional DCoH gene. J Biol Chem. 2002 Aug 9;277(32):28884-91. doi:10.1074/jbc.M201983200. Epub 2002 May 13. PMID: 12011081.

Crabtree GR, Olson EN. NFAT signaling: choreographing the social lives ofcells. Cell. 2002 Apr;109 Suppl:S67-79. doi: 10.1016/s0092-8674(02)00699-2.PMID: 11983154.

Rando OJ, Zhao K, Janmey P, Crabtree GR. Phosphatidylinositol-dependentactin filament binding by the SWI/SNF-like BAF chromatin remodeling complex.Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2824-9. doi: 10.1073/pnas.032662899.PMID: 11880634; PMCID: PMC122432.

Graef IA, Chen F, Crabtree GR. NFAT signaling in vertebrate development.Curr Opin Genet Dev. 2001 Oct;11(5):505-12. doi: 10.1016/s0959-437x(00)00225-2.PMID: 11532391.

Graef IA, Chen F, Chen L, Kuo A, Crabtree GR. Signals transduced byCa(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 2001Jun 29;105(7):863-75. doi: 10.1016/s0092-8674(01)00396-8. PMID: 11439183.

Biggar SR, Crabtree GR. Cell signaling can direct either binary or gradedtranscriptional responses. EMBO J. 2001 Jun 15;20(12):3167-76. doi:10.1093/emboj/20.12.3167. PMID: 11406593; PMCID: PMC150188.

Neilson J, Stankunas K, Crabtree GR. Monitoring the duration of antigen-receptor occupancy by calcineurin/glycogen-synthase-kinase-3 control of NF-ATnuclear shuttling. Curr Opin Immunol. 2001 Jun;13(3):346-50. doi:10.1016/s0952-7915(00)00225-9. PMID: 11406367.

Graef IA, Gastier JM, Francke U, Crabtree GR. Evolutionary relationshipsamong Rel domains indicate functional diversification by recombination. ProcNatl Acad Sci U S A. 2001 May 8;98(10):5740-5. doi: 10.1073/pnas.101602398.PMID: 11344309; PMCID: PMC33283.

Vogel KW, Briesewitz R, Wandless TJ, Crabtree GR. Calcineurin inhibitorsand the generalization of the presenting protein strategy. Adv Protein Chem.2001;56:253-91. doi: 10.1016/s0065-3233(01)56008-8. PMID: 11329856.

Stankunas K, Graef IA, Neilson JR, Park SH, Crabtree GR. Signaling throughcalcium, calcineurin, and NF-AT in lymphocyte activation and development. ColdSpring Harb Symp Quant Biol. 1999;64:505-16. doi: 10.1101/sqb.1999.64.505. PMID:11232327.

Behrens A, Sabapathy K, Graef I, Cleary M, Crabtree GR, Wagner EF. JunN-terminal kinase 2 modulates thymocyte apoptosis and T cell activation throughc-Jun and nuclear factor of activated T cell (NF-AT). Proc Natl Acad Sci U S A.2001 Feb 13;98(4):1769-74. doi: 10.1073/pnas.98.4.1769. PMID: 11172026; PMCID:PMC29332.

Chi TH, Crabtree GR. Perspectives: signal transduction. Inositol phosphatesin the nucleus. Science. 2000 Mar 17;287(5460):1937-9. doi:10.1126/science.287.5460.1937. PMID: 10755944.

Crabtree GR. Calcium, calcineurin, and the control of transcription. J BiolChem. 2001 Jan 26;276(4):2313-6. doi: 10.1074/jbc.R000024200. Epub 2000 Nov 28.PMID: 11096121.

Stewart S, Crabtree GR. Transcription. Regulation of the regulators.Nature. 2000 Nov 2;408(6808):46-7. doi: 10.1038/35040690. PMID: 11081497.

Rose RB, Bayle JH, Endrizzi JA, Cronk JD, Crabtree GR, Alber T. Structuralbasis of dimerization, coactivator recognition and MODY3 mutations inHNF-1alpha. Nat Struct Biol. 2000 Sep;7(9):744-8. doi: 10.1038/78966. PMID:10966642.

Wülfing C, Bauch A, Crabtree GR, Davis MM. The vav exchange factor is anessential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface. Proc Natl Acad Sci U S A. 2000 Aug29;97(18):10150-5. doi: 10.1073/pnas.97.18.10150. PMID: 10963677; PMCID:PMC27768.

Bauch A, Alt FW, Crabtree GR, Snapper SB. The cytoskeleton in lymphocytesignaling. Adv Immunol. 2000;75:89-114. doi: 10.1016/s0065-2776(00)75002-4.PMID: 10879282.

Biggar SR, Crabtree GR. Chemically regulated transcription factors revealthe persistence of repressor-resistant transcription after disrupting activatorfunction. J Biol Chem. 2000 Aug 18;275(33):25381-90. doi:10.1074/jbc.M002991200. PMID: 10801867.

Rando OJ, Zhao K, Crabtree GR. Searching for a function for nuclear actin.Trends Cell Biol. 2000 Mar;10(3):92-7. doi: 10.1016/s0962-8924(99)01713-4. PMID:10675902.

Graef IA, Mermelstein PG, Stankunas K, Neilson JR, Deisseroth K, Tsien RW,Crabtree GR. L-type calcium channels and GSK-3 regulate the activity of NF-ATc4in hippocampal neurons. Nature. 1999 Oct 14;401(6754):703-8. doi: 10.1038/44378.PMID: 10537109.

Biggar SR, Crabtree GR. Continuous and widespread roles for the Swi-Snfcomplex in transcription. EMBO J. 1999 Apr 15;18(8):2254-64. doi:10.1093/emboj/18.8.2254. PMID: 10205178; PMCID: PMC1171308.

Crabtree GR. Generic signals and specific outcomes: signaling through Ca2+,calcineurin, and NF-AT. Cell. 1999 Mar 5;96(5):611-4. doi:10.1016/s0092-8674(00)80571-1. PMID: 10089876.

Briesewitz R, Ray GT, Wandless TJ, Crabtree GR. Affinity modulation ofsmall-molecule ligands by borrowing endogenous protein surfaces. Proc Natl AcadSci U S A. 1999 Mar 2;96(5):1953-8. doi: 10.1073/pnas.96.5.1953. PMID: 10051576;PMCID: PMC26718.

Penninger JM, Crabtree GR. The actin cytoskeleton and lymphocyteactivation. Cell. 1999 Jan 8;96(1):9-12. doi: 10.1016/s0092-8674(00)80954-x.PMID: 9989492.

Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR. Rapid andphosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatinafter T lymphocyte receptor signaling. Cell. 1998 Nov 25;95(5):625-36. doi:10.1016/s0092-8674(00)81633-5. PMID: 9845365.

Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U. Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genesare dispersed in the human genome. Genomics. 1998 Jul 1;51(1):140-3. doi:10.1006/geno.1998.5343. PMID: 9693044.

Holsinger LJ, Graef IA, Swat W, Chi T, Bautista DM, Davidson L, Lewis RS,Alt FW, Crabtree GR. Defects in actin-cap formation in Vav-deficient miceimplicate an actin requirement for lymphocyte signal transduction. Curr Biol.1998 May 7;8(10):563-72. doi: 10.1016/s0960-9822(98)70225-8. PMID: 9601640.

Klemm JD, Schreiber SL, Crabtree GR. Dimerization as a regulatory mechanismin signal transduction. Annu Rev Immunol. 1998;16:569-92. doi:10.1146/annurev.immunol.16.1.569. PMID: 9597142.

de la Pompa JL, Timmerman LA, Takimoto H, Yoshida H, Elia AJ, Samper E,Potter J, Wakeham A, Marengere L, Langille BL, Crabtree GR, Mak TW. Role of theNF-ATc transcription factor in morphogenesis of cardiac valves and septum.Nature. 1998 Mar 12;392(6672):182-6. doi: 10.1038/32419. PMID: 9515963.

Borchardt A, Liberles SD, Biggar SR, Crabtree GR, Schreiber SL. Smallmolecule-dependent genetic selection in stochastic nanodroplets as a means ofdetecting protein-ligand interactions on a large scale. Chem Biol. 1997Dec;4(12):961-8. doi: 10.1016/s1074-5521(97)90304-5. PMID: 9427663.

Bayle JH, Crabtree GR. Protein acetylation: more than chromatinmodification to regulate transcription. Chem Biol. 1997 Dec;4(12):885-8. doi:10.1016/s1074-5521(97)90296-9. PMID: 9427654.

Yoshida H, Nishina H, Takimoto H, Marengère LE, Wakeham AC, Bouchard D,Kong YY, Ohteki T, Shahinian A, Bachmann M, Ohashi PS, Penninger JM, CrabtreeGR, Mak TW. The transcription factor NF-ATc1 regulates lymphocyte proliferationand Th2 cytokine production. Immunity. 1998 Jan;8(1):115-24. doi:10.1016/s1074-7613(00)80464-1. PMID: 9462517.

Wang W, Chi T, Xue Y, Zhou S, Kuo A, Crabtree GR. Architectural DNA bindingby a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-relatedcomplexes. Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):492-8. doi:10.1073/pnas.95.2.492. PMID: 9435219; PMCID: PMC18447.

Fiorentino DF, Crabtree GR. Characterization of Saccharomyces cerevisiaedna2 mutants suggests a role for the helicase late in S phase. Mol Biol Cell.1997 Dec;8(12):2519-37. doi: 10.1091/mbc.8.12.2519. PMID: 9398673; PMCID:PMC25725.

Graef IA, Holsinger LJ, Diver S, Schreiber SL, Crabtree GR. Proximity andorientation underlie signaling by the non-receptor tyrosine kinase ZAP70. EMBOJ. 1997 Sep 15;16(18):5618-28. doi: 10.1093/emboj/16.18.5618. PMID: 9312021;PMCID: PMC1170194.

Timmerman LA, Healy JI, Ho SN, Chen L, Goodnow CC, Crabtree GR. Redundantexpression but selective utilization of nuclear factor of activated T cellsfamily members. J Immunol. 1997 Sep 15;159(6):2735-40. PMID: 9300694.

Klemm JD, Beals CR, Crabtree GR. Rapid targeting of nuclear proteins to thecytoplasm. Curr Biol. 1997 Sep 1;7(9):638-44. doi:10.1016/s0960-9822(06)00290-9. PMID: 9285717.

Graef IA, Crabtree GR. The transcriptional paradox: octamer factors and Band T cells. Science. 1997 Jul 11;277(5323):193-4. doi:10.1126/science.277.5323.193. PMID: 9235633.

Healy JI, Dolmetsch RE, Timmerman LA, Cyster JG, Thomas ML, Crabtree GR,Lewis RS, Goodnow CC. Different nuclear signals are activated by the B cellreceptor during positive versus negative signaling. Immunity. 1997Apr;6(4):419-28. doi: 10.1016/s1074-7613(00)80285-x. PMID: 9133421.

Beals CR, Clipstone NA, Ho SN, Crabtree GR. Nuclear localization of NF-ATcby a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.Genes Dev. 1997 Apr 1;11(7):824-34. doi: 10.1101/gad.11.7.824. PMID: 9106655.

Beals CR, Sheridan CM, Turck CW, Gardner P, Crabtree GR. Nuclear export ofNF-ATc enhanced by glycogen synthase kinase-3. Science. 1997 Mar28;275(5308):1930-4. doi: 10.1126/science.275.5308.1930. PMID: 9072970.

Freiberg RA, Spencer DM, Choate KA, Duh HJ, Schreiber SL, Crabtree GR,Khavari PA. Fas signal transduction triggers either proliferation or apoptosisin human fibroblasts. J Invest Dermatol. 1997 Feb;108(2):215-9. doi:10.1111/1523-1747.ep12334273. PMID: 9008237.

Wolfe SA, Zhou P, Dötsch V, Chen L, You A, Ho SN, Crabtree GR, Wagner G,Verdine GL. Unusual Rel-like architecture in the DNA-binding domain of thetranscription factor NFATc. Nature. 1997 Jan 9;385(6612):172-6. doi:10.1038/385172a0. PMID: 8990122.

Freiberg RA, Spencer DM, Choate KA, Peng PD, Schreiber SL, Crabtree GR,Khavari PA. Specific triggering of the Fas signal transduction pathway in normalhuman keratinocytes. J Biol Chem. 1996 Dec 6;271(49):31666-9. doi:10.1074/jbc.271.49.31666. PMID: 8940187.

Crabtree GR, Schreiber SL. Three-part inventions: intracellular signalingand induced proximity. Trends Biochem Sci. 1996 Nov;21(11):418-22. doi:10.1016/s0968-0004(96)20027-1. PMID: 8987395.

Timmerman LA, Clipstone NA, Ho SN, Northrop JP, Crabtree GR. Rapidshuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression.Nature. 1996 Oct 31;383(6603):837-40. doi: 10.1038/383837a0. PMID: 8893011.

Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, KalpanaGV, Goff SP, Yaniv M, Workman JL, Crabtree GR. Purification and biochemicalheterogeneity of the mammalian SWI-SNF complex. EMBO J. 1996 Oct1;15(19):5370-82. PMID: 8895581; PMCID: PMC452280.

Belshaw PJ, Spencer DM, Crabtree GR, Schreiber SL. Controlling programmedcell death with a cyclophilin-cyclosporin-based chemical inducer ofdimerization. Chem Biol. 1996 Sep;3(9):731-8. doi:10.1016/s1074-5521(96)90249-5. PMID: 8939689.

Ho S, Clipstone N, Timmermann L, Northrop J, Graef I, Fiorentino D, NourseJ, Crabtree GR. The mechanism of action of cyclosporin A and FK506. Clin ImmunolImmunopathol. 1996 Sep;80(3 Pt 2):S40-5. doi: 10.1006/clin.1996.0140. PMID:8811062.

Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR. Diversity andspecialization of mammalian SWI/SNF complexes. Genes Dev. 1996 Sep1;10(17):2117-30. doi: 10.1101/gad.10.17.2117. PMID: 8804307.

Ho SN, Biggar SR, Spencer DM, Schreiber SL, Crabtree GR. Dimeric ligandsdefine a role for transcriptional activation domains in reinitiation. Nature.1996 Aug 29;382(6594):822-6. doi: 10.1038/382822a0. PMID: 8752278.

Spencer DM, Belshaw PJ, Chen L, Ho SN, Randazzo F, Crabtree GR, SchreiberSL. Functional analysis of Fas signaling in vivo using synthetic inducers ofdimerization. Curr Biol. 1996 Jul 1;6(7):839-47. doi:10.1016/s0960-9822(02)00607-3. PMID: 8805308.

Belshaw PJ, Ho SN, Crabtree GR, Schreiber SL. Controlling proteinassociation and subcellular localization with a synthetic ligand that inducesheterodimerization of proteins. Proc Natl Acad Sci U S A. 1996 May14;93(10):4604-7. doi: 10.1073/pnas.93.10.4604. PMID: 8643450; PMCID: PMC39324.

Fanger CM, Hoth M, Crabtree GR, Lewis RS. Characterization of T cellmutants with defects in capacitative calcium entry: genetic evidence for thephysiological roles of CRAC channels. J Cell Biol. 1995 Nov;131(3):655-67. doi:10.1083/jcb.131.3.655. PMID: 7593187; PMCID: PMC2120614.

Holsinger LJ, Spencer DM, Austin DJ, Schreiber SL, Crabtree GR. Signaltransduction in T lymphocytes using a conditional allele of Sos. Proc Natl AcadSci U S A. 1995 Oct 10;92(21):9810-4. doi: 10.1073/pnas.92.21.9810. PMID:7568223; PMCID: PMC40892.

Spencer DM, Graef I, Austin DJ, Schreiber SL, Crabtree GR. A generalstrategy for producing conditional alleles of Src-like tyrosine kinases. ProcNatl Acad Sci U S A. 1995 Oct 10;92(21):9805-9. doi: 10.1073/pnas.92.21.9805.PMID: 7568222; PMCID: PMC40891.

Ho SN, Thomas DJ, Timmerman LA, Li X, Francke U, Crabtree GR. NFATc3, alymphoid-specific NFATc family member that is calcium-regulated and exhibitsdistinct DNA binding specificity. J Biol Chem. 1995 Aug 25;270(34):19898-907.doi: 10.1074/jbc.270.34.19898. PMID: 7650004.

Serafini AT, Lewis RS, Clipstone NA, Bram RJ, Fanger C, Fiering S,Herzenberg LA, Crabtree GR. Isolation of mutant T lymphocytes with defects incapacitative calcium entry. Immunity. 1995 Aug;3(2):239-50. doi:10.1016/1074-7613(95)90093-4. PMID: 7648396.

Zheng XF, Florentino D, Chen J, Crabtree GR, Schreiber SL. TOR kinasedomains are required for two distinct functions, only one of which is inhibitedby rapamycin. Cell. 1995 Jul 14;82(1):121-30. doi: 10.1016/0092-8674(95)90058-6.PMID: 7606777.

Endrizzi JA, Cronk JD, Wang W, Crabtree GR, Alber T. Crystal structure ofDCoH, a bifunctional, protein-binding transcriptional coactivator. Science. 1995Apr 28;268(5210):556-9. doi: 10.1126/science.7725101. Erratum in: Science 1995Jun 9;268(5216):1421. PMID: 7725101.

Schreiber SL, Crabtree GR. Immunophilins, ligands, and the control ofsignal transduction. Harvey Lect. 1995-1996;91:99-114. PMID: 9127988.

Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree GR,Francke U. Cloning and chromosomal localization of the human and murine genesfor the T-cell transcription factors NFATc and NFATp. Cytogenet Cell Genet.1995;68(3-4):185-91. doi: 10.1159/000133910. PMID: 7842733.

Kalpana GV, Marmon S, Wang W, Crabtree GR, Goff SP. Binding and stimulationof HIV-1 integrase by a human homolog of yeast transcription factor SNF5.Science. 1994 Dec 23;266(5193):2002-6. doi: 10.1126/science.7801128. PMID:7801128.

Nourse J, Firpo E, Flanagan WM, Coats S, Polyak K, Lee MH, Massague J,Crabtree GR, Roberts JM. Interleukin-2-mediated elimination of the p27Kip1cyclin-dependent kinase inhibitor prevented by rapamycin. Nature. 1994 Dec8;372(6506):570-3. doi: 10.1038/372570a0. PMID: 7990932.

Pruschy MN, Spencer DM, Kapoor TM, Miyake H, Crabtree GR, Schreiber SL.Mechanistic studies of a signaling pathway activated by the organic dimerizerFK1012. Chem Biol. 1994 Nov;1(3):163-72. doi: 10.1016/1074-5521(94)90006-x.PMID: 9383386.

Austin DJ, Crabtree GR, Schreiber SL. Proximity versus allostery: the roleof regulated protein dimerization in biology. Chem Biol. 1994 Nov;1(3):131-6.doi: 10.1016/1074-5521(94)90002-7. PMID: 9383382.

Clipstone NA, Fiorentino DF, Crabtree GR. Molecular analysis of theinteraction of calcineurin with drug-immunophilin complexes. J Biol Chem. 1994Oct 21;269(42):26431-7. PMID: 7523407.

Dunaief JL, Strober BE, Guha S, Khavari PA, Alin K, Luban J, Begemann M,Crabtree GR, Goff SP. The retinoblastoma protein and BRG1 form a complex andcooperate to induce cell cycle arrest. Cell. 1994 Oct 7;79(1):119-30. doi:10.1016/0092-8674(94)90405-7. PMID: 7923370.

Ho SN, Boyer SH, Schreiber SL, Danishefsky SJ, Crabtree GR. Specificinhibition of formation of transcription complexes by a calicheamicinoligosaccharide: a paradigm for the development of transcriptional antagonists.Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9203-7. doi:10.1073/pnas.91.20.9203. PMID: 7937742; PMCID: PMC44780.

Bram RJ, Crabtree GR. Calcium signalling in T cells stimulated by acyclophilin B-binding protein. Nature. 1994 Sep 22;371(6495):355-8. doi:10.1038/371355a0. PMID: 7522304.

Northrop JP, Ho SN, Chen L, Thomas DJ, Timmerman LA, Nolan GP, Admon A,Crabtree GR. NF-AT components define a family of transcription factors targetedin T-cell activation. Nature. 1994 Jun 9;369(6480):497-502. doi:10.1038/369497a0. PMID: 8202141.

Crabtree GR, Clipstone NA. Signal transmission between the plasma membraneand nucleus of T lymphocytes. Annu Rev Biochem. 1994;63:1045-83. doi:10.1146/annurev.bi.63.070194.005145. PMID: 7979236.

Ho S, Timmerman L, Northrop J, Crabtree GR. Cloning and characterization ofNF-ATc and NF-ATp: the cytoplasmic components of NF-AT. Adv Exp Med Biol.1994;365:167-73. doi: 10.1007/978-1-4899-0987-9_17. PMID: 7887301.

Flanagan WM, Crabtree GR. Rapamycin inhibits p34cdc2 expression and arrestsT lymphocyte proliferation at the G1/S transition. Ann N Y Acad Sci. 1993 Nov30;696:31-7. doi: 10.1111/j.1749-6632.1993.tb17139.x. PMID: 8109837.

Clipstone NA, Crabtree GR. Calcineurin is a key signaling enzyme in Tlymphocyte activation and the target of the immunosuppressive drugs cyclosporinA and FK506. Ann N Y Acad Sci. 1993 Nov 30;696:20-30. doi:10.1111/j.1749-6632.1993.tb17138.x. PMID: 7509131.

Spencer DM, Wandless TJ, Schreiber SL, Crabtree GR. Controlling signaltransduction with synthetic ligands. Science. 1993 Nov 12;262(5136):1019-24.doi: 10.1126/science.7694365. PMID: 7694365.

Khavari PA, Peterson CL, Tamkun JW, Mendel DB, Crabtree GR. BRG1 contains aconserved domain of the SWI2/SNF2 family necessary for normal mitotic growth andtranscription. Nature. 1993 Nov 11;366(6451):170-4. doi: 10.1038/366170a0. PMID:8232556.

Bram RJ, Hung DT, Martin PK, Schreiber SL, Crabtree GR. Identification ofthe immunophilins capable of mediating inhibition of signal transduction bycyclosporin A and FK506: roles of calcineurin binding and cellular location. MolCell Biol. 1993 Aug;13(8):4760-9. doi: 10.1128/mcb.13.8.4760. PMID: 7687744;PMCID: PMC360102.

Hansen LP, Crabtree GR. Regulation of the HNF-1 homeodomain proteins byDCoH. Curr Opin Genet Dev. 1993 Apr;3(2):246-53. doi:10.1016/0959-437x(93)90030-s. PMID: 8504250.

Milatovich A, Mendel DB, Crabtree GR, Francke U. Genes for the dimerizationcofactor of hepatocyte nuclear factor-1 alpha (DCOH) are on human and murinechromosomes 10. Genomics. 1993 Apr;16(1):292-5. doi: 10.1006/geno.1993.1182.PMID: 8486378.

Northrop JP, Ullman KS, Crabtree GR. Characterization of the nuclear andcytoplasmic components of the lymphoid-specific nuclear factor of activated Tcells (NF-AT) complex. J Biol Chem. 1993 Feb 5;268(4):2917-23. PMID: 8428966.

Ullman KS, Northrop JP, Admon A, Crabtree GR. Jun family members arecontrolled by a calcium-regulated, cyclosporin A-sensitive signaling pathway inactivated T lymphocytes. Genes Dev. 1993 Feb;7(2):188-96. doi:10.1101/gad.7.2.188. PMID: 8436291.

Citron BA, Davis MD, Milstien S, Gutierrez J, Mendel DB, Crabtree GR,Kaufman S. Identity of 4a-carbinolamine dehydratase, a component of thephenylalanine hydroxylation system, and DCoH, a transregulator of homeodomainproteins. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11891-4. doi:10.1073/pnas.89.24.11891. PMID: 1465414; PMCID: PMC50663.

Kuo CJ, Chung J, Fiorentino DF, Flanagan WM, Blenis J, Crabtree GR.Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase.Nature. 1992 Jul 2;358(6381):70-3. doi: 10.1038/358070a0. PMID: 1614535.

Chung J, Kuo CJ, Crabtree GR, Blenis J. Rapamycin-FKBP specifically blocksgrowth-dependent activation of and signaling by the 70 kd S6 protein kinases.Cell. 1992 Jun 26;69(7):1227-36. doi: 10.1016/0092-8674(92)90643-q. PMID:1377606.

Clipstone NA, Crabtree GR. Identification of calcineurin as a keysignalling enzyme in T-lymphocyte activation. Nature. 1992 Jun25;357(6380):695-7. doi: 10.1038/357695a0. PMID: 1377362.

Northrop JP, Crabtree GR, Mattila PS. Negative regulation of interleukin 2transcription by the glucocorticoid receptor. J Exp Med. 1992 May1;175(5):1235-45. doi: 10.1084/jem.175.5.1235. PMID: 1569395; PMCID: PMC2119221.

Schreiber SL, Crabtree GR. The mechanism of action of cyclosporin A andFK506. Immunol Today. 1992 Apr;13(4):136-42. doi: 10.1016/0167-5699(92)90111-J.PMID: 1374612.

Kuo CJ, Conley PB, Chen L, Sladek FM, Darnell JE Jr, Crabtree GR. Atranscriptional hierarchy involved in mammalian cell-type specification. Nature.1992 Jan 30;355(6359):457-61. doi: 10.1038/355457a0. PMID: 1734282.

Flanagan WM, Crabtree GR. In vitro transcription faithfully reflectingT-cell activation requirements. J Biol Chem. 1992 Jan 5;267(1):399-406. PMID:1730605.

Riegel JS, Corthesy B, Flanagan WM, Crabtree GR. Regulation of theinterleukin-2 gene. Chem Immunol. 1992;51:266-98. PMID: 1567544.

Mendel DB, Khavari PA, Conley PB, Graves MK, Hansen LP, Admon A, CrabtreeGR. Characterization of a cofactor that regulates dimerization of a mammalianhomeodomain protein. Science. 1991 Dec 20;254(5039):1762-7. doi:10.1126/science.1763325. PMID: 1763325.

Ullman KS, Flanagan WM, Cothesy B, Kuo P, Northrop JP, Crabtree GR. Site ofaction of cyclosporine and FK 506 in the pathways of communication between theT-lymphocyte antigen receptor and the early activation genes. Transplant Proc.1991 Dec;23(6):2845. PMID: 1721294.

Ullman KS, Flanagan WM, Edwards CA, Crabtree GR. Activation of early geneexpression in T lymphocytes by Oct-1 and an inducible protein, OAP40. Science.1991 Oct 25;254(5031):558-62. doi: 10.1126/science.1683003. PMID: 1683003.

Flanagan WM, Corthésy B, Bram RJ, Crabtree GR. Nuclear association of aT-cell transcription factor blocked by FK-506 and cyclosporin A. Nature. 1991Aug 29;352(6338):803-7. doi: 10.1038/352803a0. PMID: 1715516.

Kuo CJ, Mendel DB, Hansen LP, Crabtree GR. Independent regulation of HNF-1alpha and HNF-1 beta by retinoic acid in F9 teratocarcinoma cells. EMBO J. 1991Aug;10(8):2231-6. PMID: 2065662; PMCID: PMC452912.

Mendel DB, Hansen LP, Graves MK, Conley PB, Crabtree GR. HNF-1 alpha andHNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activationdomains, and form heterodimers in vitro. Genes Dev. 1991 Jun;5(6):1042-56. doi:10.1101/gad.5.6.1042. PMID: 2044952.

Fraser JD, Irving BA, Crabtree GR, Weiss A. Regulation of interleukin-2gene enhancer activity by the T cell accessory molecule CD28. Science. 1991 Jan18;251(4991):313-6. doi: 10.1126/science.1846244. PMID: 1846244.

Mendel DB, Crabtree GR. HNF-1, a member of a novel class of dimerizinghomeodomain proteins. J Biol Chem. 1991 Jan 15;266(2):677-80. PMID: 1985954.

Kuo CJ, Conley PB, Hsieh CL, Francke U, Crabtree GR. Molecular cloning,functional expression, and chromosomal localization of mouse hepatocyte nuclearfactor 1. Proc Natl Acad Sci U S A. 1990 Dec;87(24):9838-42. doi:10.1073/pnas.87.24.9838. PMID: 2263635; PMCID: PMC55269.

Mattila PS, Ullman KS, Fiering S, Emmel EA, McCutcheon M, Crabtree GR,Herzenberg LA. The actions of cyclosporin A and FK506 suggest a novel step inthe activation of T lymphocytes. EMBO J. 1990 Dec;9(13):4425-33. PMID: 1702384;PMCID: PMC552235.

Fiering S, Northrop JP, Nolan GP, Mattila PS, Crabtree GR, Herzenberg LA.Single cell assay of a transcription factor reveals a threshold in transcriptionactivated by signals emanating from the T-cell antigen receptor. Genes Dev. 1990Oct;4(10):1823-34. doi: 10.1101/gad.4.10.1823. PMID: 2123468.

Verweij CL, Guidos C, Crabtree GR. Cell type specificity and activationrequirements for NFAT-1 (nuclear factor of activated T-cells) transcriptionalactivity determined by a new method using transgenic mice to assaytranscriptional activity of an individual nuclear factor. J Biol Chem. 1990 Sep15;265(26):15788-95. PMID: 2394747.

Baumhueter S, Mendel DB, Conley PB, Kuo CJ, Turk C, Graves MK, Edwards CA,Courtois G, Crabtree GR. HNF-1 shares three sequence motifs with the POU domainproteins and is identical to LF-B1 and APF. Genes Dev. 1990 Mar;4(3):372-9. doi:10.1101/gad.4.3.372. PMID: 1970973.

Ullman KS, Northrop JP, Verweij CL, Crabtree GR. Transmission of signalsfrom the T lymphocyte antigen receptor to the genes responsible for cellproliferation and immune function: the missing link. Annu Rev Immunol.1990;8:421-52. doi: 10.1146/annurev.iy.08.040190.002225. PMID: 2188669.

Emmel EA, Verweij CL, Durand DB, Higgins KM, Lacy E, Crabtree GR.Cyclosporin A specifically inhibits function of nuclear proteins involved in Tcell activation. Science. 1989 Dec 22;246(4937):1617-20. doi:10.1126/science.2595372. PMID: 2595372.

Crabtree GR. Contingent genetic regulatory events in T lymphocyteactivation. Science. 1989 Jan 20;243(4889):355-61. doi: 10.1126/science.2783497.PMID: 2783497.

Baumhueter S, Courtois G, Morgan JG, Crabtree GR. The role of HNF-1 inliver-specific gene expression. Ann N Y Acad Sci. 1989;557:272-8, discussion279. doi: 10.1111/j.1749-6632.1989.tb24020.x. PMID: 2786698.

Courtois G, Baumhueter S, Crabtree GR. Purified hepatocyte nuclear factor 1interacts with a family of hepatocyte-specific promoters. Proc Natl Acad Sci U SA. 1988 Nov;85(21):7937-41. doi: 10.1073/pnas.85.21.7937. PMID: 2460858; PMCID:PMC282328.

Baumhueter S, Courtois G, Crabtree GR. A variant nuclear protein indedifferentiated hepatoma cells binds to the same functional sequences in thebeta fibrinogen gene promoter as HNF-1. EMBO J. 1988 Aug;7(8):2485-93. PMID:2847919; PMCID: PMC457118.

Shaw JP, Utz PJ, Durand DB, Toole JJ, Emmel EA, Crabtree GR. Identificationof a putative regulator of early T cell activation genes. Science. 1988 Jul8;241(4862):202-5. doi: 10.1126/science.3260404. PMID: 3260404.

Morgan JG, Courtois G, Fourel G, Chodosh LA, Campbell L, Evans E, CrabtreeGR. Sp1, a CAAT-binding factor, and the adenovirus major late promotertranscription factor interact with functional regions of the gamma-fibrinogenpromoter. Mol Cell Biol. 1988 Jun;8(6):2628-37. doi: 10.1128/mcb.8.6.2628. PMID:3043186; PMCID: PMC363465.

Durand DB, Shaw JP, Bush MR, Replogle RE, Belagaje R, Crabtree GR.Characterization of antigen receptor response elements within the interleukin-2enhancer. Mol Cell Biol. 1988 Apr;8(4):1715-24. doi: 10.1128/mcb.8.4.1715. PMID:3260003; PMCID: PMC363332.

Chodosh LA, Carthew RW, Morgan JG, Crabtree GR, Sharp PA. The adenovirusmajor late transcription factor activates the rat gamma-fibrinogen promoter.Science. 1987 Oct 30;238(4827):684-8. doi: 10.1126/science.3672119. PMID:3672119.

Courtois G, Morgan JG, Campbell LA, Fourel G, Crabtree GR. Interaction of aliver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsinpromoters. Science. 1987 Oct 30;238(4827):688-92. doi: 10.1126/science.3499668.PMID: 3499668.

Evans E, Courtois GM, Kilian PL, Fuller GM, Crabtree GR. Induction offibrinogen and a subset of acute phase response genes involves a novel monokinewhich is mimicked by phorbol esters. J Biol Chem. 1987 Aug 5;262(22):10850-4.PMID: 2440878.

Holbrook NJ, Gulino A, Durand D, Lin Y, Crabtree GR. Transcriptionalactivity of the gibbon ape leukemia virus in the interleukin 2 gene of MLA 144cells. Virology. 1987 Jul;159(1):178-82. doi: 10.1016/0042-6822(87)90364-3.PMID: 3037778.

Morgan JG, Holbrook NJ, Crabtree GR. Nucleotide sequence of the gamma chaingene of rat fibrinogen: conserved intronic sequences. Nucleic Acids Res. 1987Mar 25;15(6):2774-6. doi: 10.1093/nar/15.6.2774. PMID: 3562236; PMCID:PMC340686.

Durand DB, Bush MR, Morgan JG, Weiss A, Crabtree GR. A 275 basepairfragment at the 5′ end of the interleukin 2 gene enhances expression from aheterologous promoter in response to signals from the T cell antigen receptor. JExp Med. 1987 Feb 1;165(2):395-407. doi: 10.1084/jem.165.2.395. PMID: 3102668;PMCID: PMC2188523.

Crabtree GR, Durand D. Control of the early activation genes of Tlymphocytes. Bioessays. 1986 Nov;5(5):220-2. doi: 10.1002/bies.950050508. PMID:3492997.

Durand DB, Kamoun M, Norris CA, Holbrook NJ, Greengard JS, Crabtree GR,Kant JA. Retroviral activation of interleukin 2 gene in a gibbon ape T celllymphoma line. J Exp Med. 1986 Nov 1;164(5):1723-34. doi:10.1084/jem.164.5.1723. PMID: 3021892; PMCID: PMC2188461.

Uzan G, Courtois G, Stanckovic Z, Crabtree GR, Marguerie G. Expression ofthe fibrinogen genes in rat megakaryocytes. Biochem Biophys Res Commun. 1986 Oct30;140(2):543-9. doi: 10.1016/0006-291x(86)90766-7. PMID: 3778466.

Siebenlist U, Durand DB, Bressler P, Holbrook NJ, Norris CA, Kamoun M, KantJA, Crabtree GR. Promoter region of interleukin-2 gene undergoes chromatinstructure changes and confers inducibility on chloramphenicol acetyltransferasegene during activation of T cells. Mol Cell Biol. 1986 Sep;6(9):3042-9. doi:10.1128/mcb.6.9.3042. PMID: 3491296; PMCID: PMC367038.

Plutzky J, Hoskins JA, Long GL, Crabtree GR. Evolution and organization ofthe human protein C gene. Proc Natl Acad Sci U S A. 1986 Feb;83(3):546-50. doi:10.1073/pnas.83.3.546. PMID: 3511471; PMCID: PMC322900.

Chen SJ, Holbrook NJ, Mitchell KF, Vallone CA, Greengard JS, Crabtree GR,Lin Y. A viral long terminal repeat in the interleukin 2 gene of a cell linethat constitutively produces interleukin 2. Proc Natl Acad Sci U S A. 1985Nov;82(21):7284-8. doi: 10.1073/pnas.82.21.7284. PMID: 3877307; PMCID:PMC390834.

Crabtree GR, Comeau CM, Fowlkes DM, Fornace AJ Jr, Malley JD, Kant JA.Evolution and structure of the fibrinogen genes. Random insertion of introns orselective loss? J Mol Biol. 1985 Sep 5;185(1):1-19. doi:10.1016/0022-2836(85)90179-2. PMID: 4046033.

Greene WC, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, KrönkeM, Svetlik P, Peffer NJ, Waldmann TA, et al. Isolation and expression ofcomplementary DNAs encoding the human interleukin 2 receptor. Cancer Res. 1985Sep;45(9 Suppl):4563s-4567s. PMID: 2990688.

Beckmann RJ, Schmidt RJ, Santerre RF, Plutzky J, Crabtree GR, Long GL. Thestructure and evolution of a 461 amino acid human protein C precursor and itsmessenger RNA, based upon the DNA sequence of cloned human liver cDNAs. NucleicAcids Res. 1985 Jul 25;13(14):5233-47. doi: 10.1093/nar/13.14.5233. PMID:2991859; PMCID: PMC321861.

Simrell CR, Margolick JB, Crabtree GR, Cossman J, Fauci AS, Jaffe ES.Lymphokine-induced phagocytosis in angiocentric immunoproliferative lesions(AIL) and malignant lymphoma arising in AIL. Blood. 1985 Jun;65(6):1469-76.PMID: 3873265.

Kant JA, Fornace AJ Jr, Saxe D, Simon MI, McBride OW, Crabtree GR.Evolution and organization of the fibrinogen locus on chromosome 4: geneduplication accompanied by transposition and inversion. Proc Natl Acad Sci U SA. 1985 Apr;82(8):2344-8. doi: 10.1073/pnas.82.8.2344. PMID: 2986113; PMCID:PMC397554.

Greene WC, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, KrönkeM, Svetlik P, Peffer NJ, Waldmann TA, et al. Molecular cloning of cDNA for thehuman interleukin-2 receptor. Haematol Blood Transfus. 1985;29:388-95. doi:10.1007/978-3-642-70385-0_80. PMID: 2993133.

Fornace AJ Jr, Cummings DE, Comeau CM, Kant JA, Crabtree GR. Structure ofthe human gamma-fibrinogen gene. Alternate mRNA splicing near the 3′ end of thegene produces gamma A and gamma B forms of gamma-fibrinogen. J Biol Chem. 1984Oct 25;259(20):12826-30. PMID: 6092346.

Leonard WJ, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, KrönkeM, Svetlik PB, Peffer NJ, Waldmann TA, et al. Molecular cloning and expressionof cDNAs for the human interleukin-2 receptor. Nature. 1984 Oct18-24;311(5987):626-31. doi: 10.1038/311626a0. PMID: 6090948.

Holbrook NJ, Lieber M, Crabtree GR. DNA sequence of the 5′ flanking regionof the human interleukin 2 gene: homologies with adult T-cell leukemia virus.Nucleic Acids Res. 1984 Jun 25;12(12):5005-13. doi: 10.1093/nar/12.12.5005.PMID: 6330695; PMCID: PMC318895.

Fornace AJ Jr, Cummings DE, Comeau CM, Kant JA, Crabtree GR. Single-copyinverted repeats associated with regional genetic duplications in gammafibrinogen and immunoglobulin genes. Science. 1984 Apr 13;224(4645):161-4. doi:10.1126/science.6322310. PMID: 6322310.

Fowlkes DM, Mullis NT, Comeau CM, Crabtree GR. Potential basis forregulation of the coordinately expressed fibrinogen genes: homology in the 5′flanking regions. Proc Natl Acad Sci U S A. 1984 Apr;81(8):2313-6. doi:10.1073/pnas.81.8.2313. PMID: 6232608; PMCID: PMC345049.

Holbrook NJ, Smith KA, Fornace AJ Jr, Comeau CM, Wiskocil RL, Crabtree GR.T-cell growth factor: complete nucleotide sequence and organization of the genein normal and malignant cells. Proc Natl Acad Sci U S A. 1984 Mar;81(6):1634-8.doi: 10.1073/pnas.81.6.1634. PMID: 6608729; PMCID: PMC344972.

Kant JA, Lord ST, Crabtree GR. Partial mRNA sequences for human A alpha, Bbeta, and gamma fibrinogen chains: evolutionary and functional implications.Proc Natl Acad Sci U S A. 1983 Jul;80(13):3953-7. doi: 10.1073/pnas.80.13.3953.PMID: 6575389; PMCID: PMC394177.

Crabtree GR, Kant JA, Fornace AJ Jr, Rauch CA, Fowlkes DM. Regulation andcharacterization of the mRNAs for the A alpha, B beta and gamma chains offibrinogen. Ann N Y Acad Sci. 1983 Jun 27;408:457-68. doi:10.1111/j.1749-6632.1983.tb23266.x. PMID: 6575701.

Kant JA, Crabtree GR. The rat fibrinogen genes. Linkage of the A alpha andgamma chain genes. J Biol Chem. 1983 Apr 25;258(8):4666-7. PMID: 6300095.

Crabtree GR, Kant JA. Organization of the rat gamma-fibrinogen gene:alternative mRNA splice patterns produce the gamma A and gamma B (gamma ‘)chains of fibrinogen. Cell. 1982 Nov;31(1):159-66. doi:10.1016/0092-8674(82)90415-9. PMID: 6897622.

Fries LF, Hall RP, Lawley TJ, Crabtree GR, Frank MM. Monocyte receptors forthe Fc portion of IgG studies with monomeric human IgG1: normal in vitroexpression of Fc gamma receptors in HLA-B8/Drw3 subjects with defective Fcgamma-mediated in vivo clearance. J Immunol. 1982 Sep;129(3):1041-9. PMID:6980915.

Crabtree GR, Kant JA. Coordinate accumulation of the mRNAs for the alpha,beta, and gamma chains of rat fibrinogen following defibrination. J Biol Chem.1982 Jul 10;257(13):7277-9. PMID: 6896326.

Crabtree GR, Bloomfield CD, Smith KA, McKenna RW, Peterson BA, HildebrandtL, Munck A. Glucocorticoid receptors and in vitro responses to glucocorticoid inacute nonlymphocytic leukemia. Cancer Res. 1981 Nov;41(11 Pt 2):4853-6. PMID:7296546.

Crabtree GR, Kant JA. Molecular cloning of cDNA for the alpha, beta, andgamma chains of rat fibrinogen. A family of coordinately regulated genes. J BiolChem. 1981 Sep 25;256(18):9718-23. PMID: 6169715.

Guyre PM, Crabtree GR, Bodwell JE, Munck A. MLC-conditioned media stimulatean increase in Fc receptors on human macrophages. J Immunol. 1981Feb;126(2):666-8. PMID: 6450248.

Crabtree GR, Munck A, Smith KA. Glucocorticoids and lymphocytes. II. Cellcycle-dependent changes in glucocorticoid receptor content. J Immunol. 1980Jul;125(1):13-7. PMID: 7381199.

Crabtree GR. Fc receptors of a human promyelocytic leukemic cell line:evidence for two types of receptors defined by binding of the staphylococcalprotein A-IgG1 complex. J Immunol. 1980 Jul;125(1):448-53. PMID: 6991603.

Crabtree GR, Munck A, Smith KA. Glucocorticoids and lymphocytes. I.Increased glucocorticoid receptor levels in antigen-stimulated lymphocytes. JImmunol. 1980 May;124(5):2430-5. PMID: 7365260.

Crabtree GR, Gillis S, Smith KA, Munck A. Mechanisms of glucocorticoid-induced immunosuppression: inhibitory effects on expression of Fc receptors andproduction of T-cell growth factor. J Steroid Biochem. 1980 Jan;12:445-9. doi:10.1016/0022-4731(80)90305-2. PMID: 6968381.

Crabtree GR, Gillis S, Smith KA, Munck A. Glucocorticoids and immuneresponses. Arthritis Rheum. 1979 Nov;22(11):1246-56. doi:10.1002/art.1780221112. PMID: 389249.

Gillis S, Crabtree GR, Smith KA. Glucocorticoid-induced inhibition of Tcell growth factor production. I. The effect on mitogen-induced lymphocyteproliferation. J Immunol. 1979 Oct;123(4):1624-31. PMID: 314468.

Gillis S, Crabtree GR, Smith KA. Glucocorticoid-induced inhibition of Tcell growth factor production. II. The effect on the in vitro generation ofcytolytic T cells. J Immunol. 1979 Oct;123(4):1632-8. PMID: 158054.

Crabtree GR, Munck A, Smith KA. Glucocorticoids inhibit expression of Fcreceptors on the human granulocytic cell line HL-60. Nature. 1979 May24;279(5711):338-9. doi: 10.1038/279338a0. PMID: 450087.

Munck A, Crabtree GR, Smith KA. Glucocorticoid receptors and actions in ratthymocytes and immunologically stimulated human peripheral lymphocytes. MonogrEndocrinol. 1979;12:341-55. doi: 10.1007/978-3-642-81265-1_19. PMID: 492174.

Crabtree GR, Smith KA, Munck A. Glucocorticoid receptors and sensitivity ofisolated human leukemia and lymphoma cells. Cancer Res. 1978 Nov;38(11 Pt2):4268-72. PMID: 279402.

Munck A, Crabtree GR, Smith KA. Effects and receptors of glucocorticoids inrat thymus cells and human peripheral lymphocytes. J Toxicol Environ Health.1978 Mar-May;4(2-3):409-25. doi: 10.1080/15287397809529668. PMID: 351204.

Smith KA, Crabtree GR, Kennedy SJ, Munck AU. Glucocorticoid receptors andglucocorticoid sensitivity of mitogen stimulated and unstimulated humanlymphocytes. Nature. 1977 Jun 9;267(5611):523-6. doi: 10.1038/267523a0. PMID:876370.

Crabtree GR, Lee JC, Cornwell GG 3rd. Letter: Autoimmune thrombocytopeniapurpura and Hashimoto’s thyroiditis. Ann Intern Med. 1975 Sep;83(3):371-2. doi:10.7326/0003-4819-83-3-371. PMID: 1242293.