Calvin was a graduate student in the laboratory and defined the transcriptional hierarchy (Nature 355, 457, 1993) the elements of which are mutated in most cases of inherited diabetes. (MODY). He also made the first observation that rapamycin interfered with the pathways that control protein synthesis (Nature 1993), an observation that was later shown to underlie the mechanism of action of this drug in both yeast and mammalian cells. This was the critical step in defining a signaling pathway that was later shown to relate membrane signals to translational control. After spending some time at Harvard, Calvin came back to Stanford in November of 2000 as an Assistant Professor of Medicine.He can be reached at cjkuo@stanford.edu