Ching-Pin Chang

CP came into the laboratory to understand the role of NFAT signaling in heart development. He and Joel Neilson found that calcineurin-NFATc3/c4 signaling function within a specific region of the myocardium to help pick the site of valve development by repressing the VEGF gene locally. Surprisingly, they found that calcineurin-NFATc1 is used two days later to regulate the morphogenesis of the valves. This interchange of signals between two adjacent tissues, both dependent upon calcineurin-NFAT is probably an excellent example of the way this pathway is used to control vertebrate morphogenesis. CP is now Assistant Professor of Medicine and he can be reached at: