Joe worked with Isabella Graef to define the role of Dyrk1a as the nuclear export kinase of NFATc family members, contributing to our understanding of the role of this kinase in producing the various phenotypes of Down Syndrome. He also studied mice containing the small molecule (MaRap) regulated allele of GSK3b made by Kryn Stankunas in the lab, showing with Karen Lui that one could rescue the mutant phenotype of the mice by administering MaRap. He is now at Genentech and he can now be reached at their web site.