Karen used mice made by Kryn Stankunas in the lab, which contain a small-molecule regulated allele of GSK3b that could be rapidly stabilized to study the developmental roles of this protein. Her work defined a surprising function of GSK3b and was published in Nature 446,, 79-82, 2007. She along with Hank Bayle also showed that phenotypes in these mice could be rescued by small molecule administration. She moved to London in Dec 2006 and joined the Developmental Biology faculty of the University College of London. She can be reached at: email@example.com.