Mike discovered that NF-AT was made up of two components, one (NF-ATc) was cyclosporin-sensitive and cytoplasmic and required calcium for activation (Nature 1991). The other component, (NF-ATn) was nuclear and newly induced. Mike also developed the first in vitro transcription system that faithfully reflects T lymphocyte activation requirements (Nature 1991). Mike just took over the leadership of Biology Research at Sunesis, started by Jim Wells in South San Francisco.