Neil Clipstone

Neil demonstrated that calcineurin was a key component of the lymphyocyte activation pathway and furthermore mapped out the interaction between calcineurin and cyclosporin (Nature 1992). He also developed a way of activating transcription using FK506 to recruit an activation domain to a DNA binding domain (JBC 1993). This was the first use of the two sides of a single molecule for induced dimerization and lead the way to the use of rapamycin and related molecules for the same purpose. Neil is presently an Assistant Professor at Northwestern and can be reached at: or see his web page.