Steve Biggar

Steve was an MD/PhD student in the lab and studied the role of the SWI/SNF complex in yeast. He made a ts allele of SWI-2 and used it to show that the yeast complex is continuously necessary for transcription in yeast and that it plays a semi-redundant role with GCN5. With Steffan Ho he devised the system of regulated transcription using small molecule dimerizers that Ariad is using in its gene therapy clinical trials. Finally, Steve was able to use this system in yeast to show that signaling could induce either an on-off switch or graded changes depending of the context in which the signals are received. Steve decided to be an investment banker focusing on Biotech. You can contact him at: