Researchers at Stanford devised a strange new molecule that could lead to drugs that arm genes and make cancers work against themselves. https://www.nytimes.com/2023/07/26/health/cancer-self-destruct.html An article in the New York Times by Gina Kolata featuring the design and development by the Crabtree and Gray lab of small molecules (TCIP, Transcriptional/Epigenetic Chemical Inducers of Proximity) that rewire […]
An article covering the use of Protein C for treatment of septic shock. Human Protein C was first cloned by Jorge Plutzky, a student in the Crabtree laboratory, who is now Associate Professor of Medicine at Harvard. Protein C is a critical regulator of both the innate immune response and the coagulation pathway. Jerry became […]
An article in the summarizing the use of synthetic ligands for regulated gene therapy in monkeys using the system developed by Stephan Ho and Steve Biggar in the laboratory (Nature 382, 822 1996). The article highlights the studies of Jim Wilson at the University of Penn and Mike Gilman at Ariad.
A summary of the development of synthetic ligands or CID’s and their use to activate and inactivate transcription by David Spencer, Steffan Ho and others in the Crabtree and Schreiber labs. Note the shape of the receptors in the diagram used in the article.
An article in the Science Section of the New York Times describing the work done in the Crabtree and Schreiber labs that lead to an understanding of the Ca2+/calcineurin/NF-AT signaling pathway and the mechanism of action of cyclosporin A and FK506.