Jake worked with Jose Seoane in Christina Curtis’ lab to find that sensitively to TopoII inhibitors was determined by a chromatin accessibility network. He also showed that members of this network including BAF predicted responses to TopoII inhibitor treatment in breast cancer. In April 2021 Jake joined the faculty of the OMRF.
Jeff was the first post doctoral fellow. Jeff worked with Jerry on the cloning of the fibrinogen genes in 1980 and the finding that one gene could give rise to two messages and two proteins by alternative splicing (Cell 1981), which in 1981 was news. Jeff is now Professor of Pathology at the University of […]
Dana worked with Jerry at the NIH and used an early version of bioinformatics to define the control regions of genes coordinately regulated during the inflammatory response. This lead him to define the sequence GGGAATTCCC (PNAS 81:2313, 1984) which was later shown to bind NFkB. This same method defined the sequence that we later recognized […]
Al worked with Jerry at the NIH and while the lab wrote a program to search the then newly accumulating DNA sequence data base to look for genomic repeats as evidence of gene mobility. Using this approach Al was the first to define large scale genetic repeats in the mammalian genome (Science 1983). He is […]
Nikki was the person that helped switch the interest of the lab to signaling back in 1983. She cloned the IL-2 gene and with David Durand defined the regulatory regions of the IL-2 gene. She and David began our march backward through the Ca2+/Calcineurin/NF-AT signaling pathway in 1982. Nikki inherited Jerry’s lab when he left […]
Michael, along with Nikki Holbrook, initiated the studies on signal transduction in the lab. He is now Professor of Pathology and Microbiology at USC/Norris Cancer Center in Los Angeles. His e.mail address is: lieber@hsc.usc.edu Jorge Plutzy: cloned the Protein C cDNA and gene while in the lab and studied human variations in the gene during […]
Linda joined our lab as a technician at the NIH and came with us to Stanford. She helped initiate several new technologies in our lab and in 1988 she joined DNAX (now SP-Bio) and managed the gene targeting group for many years. She is now managing her family here in Palo Alto.
David joined the lab when we moved to Stanford University. He defined the regulatory regions of the IL-2 gene, and with J.P. Shaw discovered the NF-AT transcription complex in 1987. David made the IL-2 luciferase plasmids in 1987 that have been distributed to thousands of laboratories worldwide. He went from our lab to the University […]
John Morgan came from Balintubber Ireland to the lab and defined the regulatory regions of the fibrinogen genes that Gilles later used to discover the HNF-1 transcription factor. HNF-1 was later shown by John Bell at the University of Chicago to be the major gene responsible for hereditary diabetes (MODY). John is presently a a […]
Elaine Evans came to the lab from the Department of Genetics at the University of Leichester in England. She work on expression methods for protein C and definition of the control sequences in Fibrinogen genes that were later used by Gilles Courtois to discover HNF1.