Rick Bram came to the lab after finishing his residency in Pediatrics. Rick defined the active cyclophilins and based on this information cloned the CAML protein that modulates Ca2+ influx in response to signals and interacts with the backside of the active cyclophins. Rich went to St Jude Research Institute after leaving the lab and […]
Chan worked with Neil Clipstone to define the mechanism of nuclear export of the NF-ATc1 protein by first defining mutations that prevented nuclear export and then purifying the kinases that specifically phosphorylate these sites. He found that GSK3 phosphorylates the specific sites after a still unidentified kinase primed the protein for later phosphorylation by GSK3. […]
Leslie found that the VAV exchange factor for rac was required for formation of the CAP or SMAC or immune synapse signaling complex on lymphocytes and also for T cell receptor signals to activate NFAT-dependent transcription and lead to T cell activation.. In addition, she used synthetic ligands to demonstrate that the SOS exchange factor […]
Julie Klemm developed the system for using synthetic ligands to regulate the export and hence inactivation of nuclear proteins. She used this to developed a quick and effective assay for nuclear export sequences. She went to work at Incyt after leaving the lab and now has her own group there. She can be reached at […]
Luika was a graduate student in the lab and made an important contribution to the understanding of the mechanism of discrimination of Calcium signals when she showed that the NF-ATc family of transcription factors have the ability to distinguish between calcium currents derived from the IP3 receptor versus the cell membrane CRAC channel (Nature 1996). […]
David was a MD/PhD student in the lab and studied the mechanism of action of the Tor signaling pathway in yeast and mammalian cells. This is the pathway that is blocked by rapamycin. He found along with Calvin Kuo that rapamycin blocked the activation of p70S6 kinase, hence making the first steps in showing that […]
Sang Ho decided to go back to his home country of Korea after finishing his post doc in the lab and can now be reached at…..: He is working in an innovative fusion of the University of Korea and biotechnology.
Roger developed a general method for synthesis of inhibitors to almost any protein based on the concept of borrowing the surface of endogenous proteins using synthetic small molecules. This approach is now in use by several biotech companies in an effort to make inhibitors of established therapeutic targets. Roger is presently a staff scientist at […]
ngela was interested in the role of the vav protein in lymphocyte activation and along with Leslie Holsinger did studies that indicated this protein was essential for formation of the immune synap ase or cap (PNAS 2000). She is now at the EMBO in Heidelberg.
Kurt came to our lab from the Chemistry Department at Stanford and worked on a general method of using the borrowed surface of endogenous intracellular proteins to make high affinity small molecule inhibitors. He is now Senior Scientist, R&D at PanVera Corporation, happily back in his favorite place in the world: the midwest and can […]